ArticleExtreme physiology & medicine2013
Applying systems biology methods to the study of human physiology in extreme environments.
Article in Extreme physiology & medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Parameter Estimation for Kinetic Models of Chemical Reaction Networks from Partial Experimental Data of Species' Concentrations.Bioengineering (Basel, Switzerland) · 2023Article
- Review
- Urine metabolite profiling of Indian Antarctic Expedition members: NMR spectroscopy-based metabolomic investigation.Heliyon · 2021Article
- Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp.Scientific reports · 2019Article
- Omics and Exercise: Global Approaches for Mapping Exercise Biological Networks.Cold Spring Harbor perspectives in medicine · 2017Review
- Metabolic systems biology: a brief primer.The Journal of physiology · 2017Review
- Precision medicine for disease modification in Parkinson disease.Nature reviews. Neurology · 2017Review
- ERS Lung Science Conference 2016 report.European respiratory review : an official journal of the European Respiratory Society · 2016Article
- Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.Molecular biology international · 2015Review
- Mitochondrial responses to extreme environments: insights from metabolomics.Extreme physiology & medicine · 2015Article
- Systems and synthetic biology approaches to alter plant cell walls and reduce biomass recalcitrance.Plant biotechnology journal · 2014Review
- The Proteome of a Healthy Human during Physical Activity under Extreme Conditions.Acta naturae · 2014Article
- Integrative physiology and systems biology: reductionism, emergence and causality.Extreme physiology & medicine · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systems biology is defined in this review as 'an iterative process of computational model building and experimental model revision with the aim of understanding or simulating complex biological systems'. We propose that, in practice, systems biology rests on three pillars: computation, the omics disciplines and repeated experimental perturbation of the system of interest. The number of ethical and physiologically relevant perturbations that can be used in experiments on healthy humans is extremely limited and principally comprises exercise, nutrition, infusions (e.g. Intralipid), some drugs and altered environment. Thus, we argue that systems biology and environmental physiology are natural symbionts for those interested in a system-level understanding of human biology. However, despite excellent progress in high-altitude genetics and several proteomics studies, systems biology research into human adaptation to extreme environments is in its infancy. A brief description and overview of systems biology in its current guise is given, followed by a mini review of computational methods used for modelling biological systems. Special attention is given to high-altitude research, metabolic network reconstruction and constraint-based modelling.
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Registered trials
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