Evidence map›Paper›PMID 23849628›Full record

ArticleMolecular cell2013

Mad2 "opens" Cdc20 for BubR1 binding.

Gina V Caldas, Jennifer G Deluca

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gina V CaldasDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Jennifer G Deluca
Colorado State University · US

Funding

Kinetochore Function in Vertebrate CellsR01GM088371 · NIGMS · COLORADO STATE UNIVERSITY · PI DELUCA, JENNIFER G · 2010 to 2018
$3.1M
NIGMS NIH HHS R01 GM088371
6 · The paper itself

Abstract

In this issue of Molecular Cell, Han et al. (2013) demonstrate that Mad2 induces a conformational change in Cdc20 that permits BubR1 binding, thereby producing the physiologically relevant APC/C(Cdc20) inhibitor.

Indexed as

Calcium-Binding ProteinsCdc20 ProteinsCell Cycle ProteinsHumansMad2 ProteinsM Phase Cell Cycle CheckpointsProtein Serine-Threonine KinasesRepressor ProteinsBUB1 protein, humanBub1 spindle checkpoint proteinCalcium-Binding ProteinsCDC20 protein, humanCdc20 ProteinsCell Cycle ProteinsMAD2L1 protein, humanMad2 ProteinsProtein Serine-Threonine KinasesRepressor Proteins

Identifiers

PMID23849628
OpenAlexW2072602519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.