ArticleThe journal of venomous animals and toxins including tropical diseases2013
Conus vexillum venom induces oxidative stress in Ehrlich's ascites carcinoma cells: an insight into the mechanism of induction.
Article in The journal of venomous animals and toxins including tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Therapeutic potency of kaempferol against Naja haje venom induced neurotoxicity, inflammation, biological activities, and antioxidant system damage: a pre-clinical antivenom evaluation.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea.Marine drugs · 2025Article
- Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications.Journal, genetic engineering & biotechnology · 2024Article
- GK-1 Induces Oxidative Stress, Mitochondrial Dysfunction, Decreased Membrane Potential, and Impaired Autophagy Flux in a Mouse Model of Breast Cancer.Antioxidants (Basel, Switzerland) · 2022Article
- Physiological and Clinical Aspects of Bioactive Peptides from Marine Animals.Antioxidants (Basel, Switzerland) · 2022Review
- Prospecting for candidate molecules fromThe journal of venomous animals and toxins including tropical diseases · 2022Article
- Cytotoxicity Studies of the Crude venom and Fractions of Persian Gulf Snail (Conus textile) on Chronic Lymphocytic Leukemia and Normal Lymphocytes.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- 3-Hydroxypropane-1,2-Diyl Dipalmitoleate-A Natural Compound with Dual Roles (CB1 Agonist/FAAH1 Blocker) in Inhibiting Ovarian Cancer Cell Line.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Proteomic analysis of Red SeaThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties.The journal of venomous animals and toxins including tropical diseases · 2018Article
- Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.Applied and environmental microbiology · 2017Article
- Antiproliferative activity of marine stingray Dasyatis sephen venom on human cervical carcinoma cell line.The journal of venomous animals and toxins including tropical diseases · 2015Article
- Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines.The journal of venomous animals and toxins including tropical diseases · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is estimated that venoms of marine cone snails (genus Conus) contain more than 100,000 different small peptides with a wide range of pharmacological and biological actions. Some of these peptides were developed into potential therapeutic agents and as molecular tools to understand biological functions of nervous and cardiovascular systems. In this study we examined the cytotoxic and anticancer properties of the marine vermivorous cone snail Conus vexillum (collected from Hurgada and Sharm El-Shaikh, Red Sea, Egypt) and suggest the possible mechanisms involved. The in vitro cytotoxic effects of Conus venom were assessed against Ehrlich's ascites carcinoma (EAC) cells.
resultsConus venom treatment resulted in concentration-dependent cytotoxicity as indicated by a lactate dehydrogenase leakage assay. Apoptotic effects were measured in vivo by measuring levels of reactive oxygen species and oxidative defense agents in albino mice injected with EAC cells. Conus venom (1.25 mg/kg) induced a significant increase (p < 0.05) in several oxidative stress biomarkers (lipid peroxidation, protein carbonyl content and reactive nitrogen intermediates) of EAC cells after 3, 6, 9 and 12 hours of venom injection. Conus venom significantly reduced (p < 0.05) the activities of oxidative defense enzymes (catalase and superoxide dismutase) as well as the total antioxidant capacity of EAC cells, as evidenced by lowered levels of reduced glutathione.
conclusionsThese results demonstrate the cytotoxic potential of C. vexillum venom by inducing oxidative stress mediated mechanisms in tumor cells and suggest that the venom contains novel molecules with potential anticancer activity.
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Registered trials
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