ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2013
Pathogenicity and genetic variation of 3 strains of Corynebacterium bovis in immunodeficient mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Prevalence of Large Academic Research Institutions and NCI Designated Cancer Centers with Corynebacterium bovis Infections among Immunodeficient Mice in the United States from 2015 to 2023.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- A Novel Strategy to Mitigate Corynebacterium bovis-Associated Hyperkeratosis in Athymic Nude Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- The Impact of Athymic Nude Mouse Stock and Colony Source on the Severity of Corynebacterium-Associated Hyperkeratosis.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A Clinical Scoring System and Impact of Athymic Nude Mouse Age onComparative medicine · 2024Article
- Article
- Establishing the Median Infectious Dose and Characterizing the Clinical Manifestations of Mouse, Rat, Cow, and HumanComparative medicine · 2023Article
- Genetic Manipulation of Corynebacterium mastitidis to Better Understand the Ocular Microbiome.Investigative ophthalmology & visual science · 2023Article
- A Clinical Scoring Systems for the Evaluation ofComparative medicine · 2022Article
- Distribution ofVeterinary sciences · 2022Article
- Metaphylactic Antibiotic Treatment to Prevent the Transmission ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Searching for a Bacteriophage Lysin to TreatComparative medicine · 2020Article
- Facility-wide Eradication ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Genotypic differences between strains of the opportunistic pathogen Corynebacterium bovis isolated from humans, cows, and rodents.PloS one · 2018Article
- Procedure for Horizontal Transfer of Patient-Derived Xenograft Tumors to EliminateJournal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Detection and Elimination ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Surveillance of a Ventilated Rack System for Corynebacterium bovis by Sampling Exhaust-Air Manifolds.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corynebacterium bovis has been associated with hyperkeratotic dermatitis and acanthosis in mice. We studied 3 different strains of C. bovis: one previously described to cause hyperkeratotic dermatitis (HAC), one that infected athymic nude mice without leading to the classic clinical signs, and one of bovine origin (ATCC 7715). The 3 strains showed a few biochemical and genetic differences. Immunodeficient nude mice were housed in 3 independent isolators and inoculated with pure cultures of the 3 strains. We studied the transmission of these C. bovis studies to isolator-bedding and contact sentinels housed for 5 to 12 wk in filter-top or wire-top cages in the respective isolators. Using a 16S rRNA-based qPCR assay, we did not find consistent differences in growth and transmission among the 3 C. bovis strains, and neither the incidence nor severity of hyperkeratosis or acanthosis differed between strains. Housing in filter-top compared with wire-top cages did not alter the morbidity associated with any of the strains. Our findings confirmed the variability in the gross and histologic changes associated with C. bovis infection of mice. Although bacteriology was a sensitive method for the detection of Corynebacterium spp., standard algorithms occasionally misidentified C. bovis and several related species. Our study demonstrates that PCR of skin swabs or feces is a sensitive and specific method for the detection of C. bovis infection in mice. An rpoB-based screen of samples from North American vivaria revealed that HAC is the predominant C. bovis strain in laboratory mice.
Indexed as
Identifiers
23849444PMC3725931W126629556What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.