ArticleExtreme physiology & medicine2012
Fluctuations in the skeletal muscle power-velocity relationship and interferon-γ after a muscle-damaging event in humans.
Article in Extreme physiology & medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury.Nutrients · 2013Trial
- What can the first 2 months tell us about outcomes after anterior cruciate ligament reconstruction?Journal of athletic training · 2015Article
- Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise.Nutrition & metabolism · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkeletal muscle power is velocity-dependent under constant load conditions. Interferon (IFN)-γ is an inflammatory cytokine that regulates skeletal muscle recovery following insult in experimental animals. It is unknown if the power-velocity relationship and IFN-γ are modulated after a muscle-damaging event in humans. Therefore, the purpose of this study was to identify the power-velocity relationship and circulating IFN-γ concentration responses to a muscle-damaging event in humans.
methodsNine healthy males participated in this study. Each subject had one leg randomly assigned as the control leg. The other leg served as the treatment leg and performed an intense-stretch-shortening cycling (SSC) exercise protocol to induce muscle damage. To measure muscle damage and the power-velocity relationship, unilateral peak isometric force and power output (forces and velocities) measurements were performed prior to, immediately after, and during the days following the SSC protocol. The circulating IFN-γ concentrations were measured in serum samples obtained prior to, immediately after, and during the days following the SSC protocol. Statistical significance of single-leg isometric force and power output data were assessed using a two-way (time and leg treatment) analysis of variance (ANOVA) with repeated measures, followed by a Tukey's honestly significant difference (HSD) to test multiple pairwise comparisons. The statistical significance of the IFN-γ data were assessed using a one-way (time) ANOVA with repeated measures, followed by a Tukey's HSD to test multiple pairwise comparisons.
resultsIn the treatment leg, significant (P < 0.05) peak isometric force deficits occurred immediately and persisted several days after the SSC protocol, thereby identifying muscle damage-induced weakness. During muscle weakness in the treatment leg, peak power was significantly (P < 0.05) depressed and the velocities at peak power were significantly (P < 0.05) slower. Interestingly, circulating IFN-γ concentrations decreased at 2 and 3 days after compared to those immediately following the SSC protocol.
conclusionWe conclude that the velocity to achieve a compromised peak power is reduced, and speculatively, the circulating IFN-γ excursion could be influential on the recovery of skeletal muscle after a muscle-damaging event in humans.
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Registered trials
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