ArticleNanoscale research letters2013
Preparation of hierarchical mesoporous CaCO3 by a facile binary solvent approach as anticancer drug carrier for etoposide.
Article in Nanoscale research letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Synthesis and Characterization of CaFeMaterials (Basel, Switzerland) · 2026Article
- Nanofibrous electrospun scaffold doped with hydroxyapatite derived from sand lobster shell (RSC advances · 2024Article
- Calcium carbonate vaterite particles for drug delivery: Advances and challenges.Materials today. Advances · 2022Review
- Hard, Soft, and Hard-Pharmaceutics · 2022Review
- Incorporation of nanogels within calcite single crystals for the storage, protection and controlled release of active compounds.Chemical science · 2021Article
- Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ-on-a-chip system.Scientific reports · 2021Article
- Biguanide-Based Synthesis of 1,3,5-Triazine Derivatives with Anticancer Activity and 1,3,5-Triazine Incorporated Calcium Citrate Nanoparticles.Molecules (Basel, Switzerland) · 2021Article
- Comparative adsorption capabilities of rubbish tissue paper-derived carbon-doped MgO and CaCOEnvironmental science and pollution research international · 2020Article
- Facile Synthesis of Calcite-Impregnated Hydrochar with High Sorption Capacity for Cu(II) from Aqueous Solution.ACS omega · 2019Article
- Modified methods of nanoparticles synthesis in pH-sensitive nano-carriers production for doxorubicin delivery on MCF-7 breast cancer cell line.International journal of nanomedicine · 2019Article
- Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis.Nanomedicine (London, England) · 2019Article
- Facile synthesis by a covalent binding reaction for pH-responsive drug release of carboxylated chitosan coated hollow mesoporous silica nanoparticles.IET nanobiotechnology · 2018Article
- Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice.Journal of labelled compounds & radiopharmaceuticals · 2018Article
- Rap2b siRNA significantly enhances the anticancer therapeutic efficacy of adriamycin in a gold nanoshell-based drug/gene co-delivery system.Oncotarget · 2017Article
- Optimization of Conditions for Cyanidin-3-OGlucoside (C3G) Nanoliposome Production by Response Surface Methodology and Cellular Uptake Studies in Caco-2 Cells.Molecules (Basel, Switzerland) · 2017Article
- Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo.Nanoscale · 2016Article
- Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery Systems.The AAPS journal · 2016Review
- Synthesis of CaCO3 Nanobelts for Drug Delivery in Cancer Therapy.Nanoscale research letters · 2015Article
- Design of Silk-Vaterite Microsphere Systems as Drug Carriers with pH-responsive Release Behavior.Journal of materials chemistry. B · 2015Article
- Optimization on condition of epigallocatechin-3-gallate (EGCG) nanoliposomes by response surface methodology and cellular uptake studies in Caco-2 cells.Nanoscale research letters · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop a nontoxic system for targeting therapy, a new highly ordered hierarchical mesoporous calcium carbonate nanospheres (CCNSs) as small drug carriers has been synthesized by a mild and facile binary solvent approach under the normal temperature and pressure. The hierarchical structure by multistage self-assembled strategy was confirmed by TEM and SEM, and a possible formation process was proposed. Due to the large fraction of voids inside the nanospheres which provides space for physical absorption, the CCNSs can stably encapsulate the anticancer drug etoposide with the drug loading efficiency as high as 39.7 wt.%, and etoposide-loaded CCNS (ECCNS) nanoparticles can dispersed well in the cell culture. Besides, the drug release behavior investigated at three different pH values showed that the release of etoposide from CCNSs was pH-sensitive. MTT assay showed that compared with free etoposide, ECCNSs exhibited a higher cell inhibition ratio against SGC-7901 cells and also decreased the toxicity of etoposide to HEK 293 T cells. The CLSM image showed that ECCNSs exhibited a high efficiency of intracellular delivery, especially in nuclear invasion. The apoptosis test revealed that etoposide entrapped in CCNSs could enhance the delivery efficiencies of drug to achieve an improved inhibition effect on cell growth. These results clearly implied that the CCNSs are a promising drug delivery system for etoposide in cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.