ArticleBMC infectious diseases2013
Dissemination of imipenem-resistant Acinetobacter baumannii with new plasmid-borne bla(OXA-72) in Taiwan.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Antimicrobial Resistance and Virulence ofAntibiotics (Basel, Switzerland) · 2026Article
- Article
- Extensively drug-resistantPeerJ · 2023Article
- Molecular Epidemiology of Carbapenem-ResistantMicrobial drug resistance (Larchmont, N.Y.) · 2022Article
- Molecular epidemiology and carbapenem resistance characteristics ofFrontiers in microbiology · 2022Article
- Colistin-phage combinations decrease antibiotic resistance inEmerging microbes & infections · 2021Article
- The Role of Uniform Meropenem Usage inAntibiotics (Basel, Switzerland) · 2021Article
- Dual Role ofAntimicrobial agents and chemotherapy · 2019Article
- Molecular Epidemiology of Emerging Carbapenem Resistance inAntimicrobial agents and chemotherapy · 2019Article
- Molecular Epidemiology of EmergingAntimicrobial agents and chemotherapy · 2018Article
- Article
- Acquisition of a High Diversity of Bacteria during the Hajj Pilgrimage, Including Acinetobacter baumannii with blaOXA-72 and Escherichia coli with blaNDM-5 Carbapenemase Genes.Antimicrobial agents and chemotherapy · 2016Article
- First Occurrence of OXA-72-Producing Acinetobacter baumannii in Serbia.Antimicrobial agents and chemotherapy · 2016Article
- Comparative Phosphoproteomics Reveals the Role of AmpC β-lactamase Phosphorylation in the Clinical Imipenem-resistant Strain Acinetobacter baumannii SK17.Molecular & cellular proteomics : MCP · 2016Article
- Whole-Genome Sequence of a European Clone II and OXA-72-Producing Acinetobacter baumannii Strain from Serbia.Genome announcements · 2015Article
- Contribution of Acinetobacter-derived cephalosporinase-30 to sulbactam resistance in Acinetobacter baumannii.Frontiers in microbiology · 2015Article
- Acquired Class D β-Lactamases.Antibiotics (Basel, Switzerland) · 2014Review
- OXA β-lactamases.Clinical microbiology reviews · 2014Review
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10 authors.
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Abstract
backgroundThe systemic surveillance of imipenem-resistant Acinetobacter baumannii (IRAB) from multicenters in Taiwan revealed the emergence of isolates with bla(OXA-72). This study described their genetic makeup, mechanism of spread, and contribution to carbapenem resistance.
methodsTwo hundred and ninety-one non-repetitive isolates of A. baumannii were collected from 10 teaching hospitals from different geographical regions in Taiwan from June 2007 to September 2007. Minimal inhibitory concentrations (MICs) were determined by agar dilution. Clonality was determined by pulsed-field gel electrophoresis. Plasmid was extracted and digested by restriction enzymes, and subsequently analyzed by electrophoresis and Southern blot for bla(OXA-72). The flanking regions of bla(OXA-72) were determined by inverse PCR. The contribution of bla(OXA-72) to imipenem MIC was determined by transforming plasmids carrying bla(OXA-72) into imipenem-susceptible A. baumannii.
resultsAmong 142 IRAB in Taiwan, 27 harbored bla(OXA-72); 22 originated from Southern Taiwan, 5 from Central Taiwan, and none from Northern Taiwan. There were two major clones. The bla(OXA-72) was identified in the plasmids of all isolates. Two genetic structures flanking plasmid-borne bla(OXA-72) were identified and shared identical sequences in certain regions; the one described in previous literature was present in only one isolate, and the new one was present in the remaining isolates. Introduction of bla(OXA-72) resulted in an increase of imipenem MIC in the transformants. The overexpression of bla(OXA-72) mRNA in response to imipenem further supported the contribution of bla(OXA-72).
conclusionsIn conclusion, isolates with new plasmid-borne blaOXA-72 were found to be disseminated successfully in Southern Taiwan. The spread of the resistance gene depended on clonal spread and dissemination of a new plasmid. Bla(OXA-72) in these isolates directly led to their imipenem-resistance.
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