ArticleNeuron2013
Modular use of peripheral input channels tunes motion-detecting circuitry.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 155 citations in OpenAlex.
- Article
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- Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Afterimages drive a shared visual motion-reversal illusion inbioRxiv : the preprint server for biology · 2026Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Broken time-reversal symmetry in visual motion detection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies.eLife · 2025Article
- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
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- Neural pathways and computations that achieve stable contrast processing tuned to natural scenes.Nature communications · 2024Article
- Article
- Broken time reversal symmetry in visual motion detection.bioRxiv : the preprint server for biology · 2024Article
- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
- Model organisms and systems in neuroethology: one hundred years of history and a look into the future.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Heterogeneity of synaptic connectivity in the fly visual system.Nature communications · 2024Article
- Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity.eLife · 2024Article
- Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila.Nature communications · 2023Article
- Fine-grained descending control of steering in walkingbioRxiv : the preprint server for biology · 2023Article
- Long-timescale anti-directional rotation ineLife · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In the visual system, peripheral processing circuits are often tuned to specific stimulus features. How this selectivity arises and how these circuits are organized to inform specific visual behaviors is incompletely understood. Using forward genetics and quantitative behavioral studies, we uncover an input channel to motion detecting circuitry in Drosophila. The second-order neuron L3 acts combinatorially with two previously known inputs, L1 and L2, to inform circuits specialized to detect moving light and dark edges. In vivo calcium imaging of L3, combined with neuronal silencing experiments, suggests a neural mechanism to achieve selectivity for moving dark edges. We further demonstrate that different innate behaviors, turning and forward movement, can be independently modulated by visual motion. These two behaviors make use of different combinations of input channels. Such modular use of input channels to achieve feature extraction and behavioral specialization likely represents a general principle in sensory systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.