ArticleNeuron2013
Olfactory stimulation selectively modulates the OFF pathway in the retina of zebrafish.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- The central histaminergic system slows visual processing in the retina and lateral geniculate nucleus of awake mice.PLoS biology · 2025Article
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- Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.Current biology : CB · 2024Article
- A Novel Cre Recombinase Mouse Strain for Cell-Specific Deletion of Floxed Genes in Ribbon Synapse-Forming Retinal Neurons.International journal of molecular sciences · 2024Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Study of a precise treatment protocol for patients with consciousness disorders based on the brain network analysis of functional magnetic resonance imaging.Frontiers in neuroscience · 2024Article
- Article
- Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study.Frontiers in neuroscience · 2023Article
- Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia.Neuroscience bulletin · 2022Article
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Optogenetic Manipulation of Olfactory Responses in Transgenic Zebrafish: A Neurobiological and Behavioral Study.International journal of molecular sciences · 2021Article
- Arousal Modulates Retinal Output.Neuron · 2020Article
- Fovea-like Photoreceptor Specializations Underlie Single UV Cone Driven Prey-Capture Behavior in Zebrafish.Neuron · 2020Article
- Correction of z-motion artefacts to allow population imaging of synaptic activity in behaving mice.The Journal of physiology · 2020Article
- GnRH-mediated olfactory and visual inputs promote mating-like behaviors in male zebrafish.PloS one · 2017Article
- Article
- Dopamine Modulates the Activity of Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms.The Journal of comparative neurology · 2015Article
- General features of the retinal connectome determine the computation of motion anticipation.eLife · 2015Article
- Neurochemical measurements in the zebrafish brain.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cross-modal regulation of visual performance by olfactory stimuli begins in the retina, where dopaminergic interneurons receive projections from the olfactory bulb. However, we do not understand how olfactory stimuli alter the processing of visual signals within the retina. We investigated this question by in vivo imaging activity in transgenic zebrafish expressing SyGCaMP2 in bipolar cell terminals and GCaMP3.5 in ganglion cells. The food-related amino acid methionine reduced the gain and increased sensitivity of responses to luminance and contrast transmitted through OFF bipolar cells but not ON. The effects of olfactory stimulus were blocked by inhibiting dopamine uptake and release. Activation of dopamine receptors increased the gain of synaptic transmission in vivo and potentiated synaptic calcium currents in isolated bipolar cells. These results indicate that olfactory stimuli alter the sensitivity of the retina through the dopaminergic regulation of presynaptic calcium channels that control the gain of synaptic transmission through OFF bipolar cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.