Evidence map›Paper›PMID 23849150›Full record

ArticleJournal of clinical epidemiology2013

The use of clinical trials in comparative effectiveness research on mental health.

Carlos Blanco, Claudia Rafful, Mark Olfson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carlos BlancoDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA. Cblanco@nyspi.columbia.edu
Claudia Rafful
Mark Olfson

Funding

Improving the Effectiveness of Treatment for Depression in HispanicsR01MH076051 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2008 to 2012
$2.8M
Interpersonal therapy for depression in Breast CancerR01CA133050 · NCI · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARKOWITZ, JOHN C · 2009 to 2013
$2.6M
Towards a Comprehensive Developmental Model of Substance Use DisordersR01DA019606 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI OLFSON, MARK · 2006 to 2016
$2.6M
2/2 Gambling Addiction: Treatment Mediators and ModeratorsR01MH082773 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2009 to 2012
$1.6M
SMART: Improving Detection & Outcome of Psychiatric Comorbidity in Drug TreatmentR01DA020783 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2006 to 2010
$1.4M
Substance Use Comorbidity Care: Evidence-Based Stepped Strategies for DepressionR01DA023973 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2009 to 2010
$1.1M
Bridging Efficacy and Effectiveness in Drug Abuse TreatmentK02DA023200 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANCO, CARLOS · 2008 to 2012
$618k
NCI NIH HHS CA133050NCI NIH HHS R01 CA133050NIDA NIH HHS DA019606NIDA NIH HHS DA020783NIDA NIH HHS DA023200NIDA NIH HHS DA023973NIDA NIH HHS K02 DA023200NIDA NIH HHS R01 DA019606NIDA NIH HHS R01 DA020783NIDA NIH HHS R01 DA023973NIMH NIH HHS MH076051NIMH NIH HHS MH082773NIMH NIH HHS R01 MH076051NIMH NIH HHS R01 MH082773
6 · The paper itself

Abstract

objectivesA large body of comparative effectiveness research (CER) focuses on the use of observational and quasi-experimental approaches. We sought to examine the use of clinical trials as a tool for CER, particularly in mental health. STUDY DESIGN AND

settingExamination of three ongoing randomized clinical trials in psychiatry addressing issues that would pose difficulties for nonexperimental CER methods.

resultsExisting statistical approaches to nonexperimental data appear insufficient to compensate for biases that may arise when the pattern of missing data cannot be properly modeled such as when there are no standards for treatment, when affected populations have limited access to treatment, or when there are high rates of treatment dropout.

conclusionClinical trials should retain an important role in CER, particularly in cases of high disorder prevalence, large expected effect sizes, difficult-to-reach populations, or when examining sequential treatments or stepped-care algorithms. Progress in CER on mental health will require careful consideration of appropriate selection between clinical trials and nonexperimental designs and on allocation of research resources to optimally inform key treatment decisions for each patient.

Indexed as

Evidence-Based MedicinePsychiatryRandomized Controlled Trials as TopicAdultBiasBreast NeoplasmsComorbidityComparative Effectiveness ResearchData Interpretation, StatisticalFemaleGamblingHealth Services AccessibilityHispanic or LatinoHumansMajor Depressive DisorderPatient ComplianceAccess to treatmentClinical trialsComparative effectiveness researchMajor depressionMental healthPathological gambling

Identifiers

PMID23849150
PMCPMC3713498

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.