ArticleJournal of biomaterials science. Polymer edition2013
Hemocompatibility of polymeric nanostructured surfaces.
Article in Journal of biomaterials science. Polymer edition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Bacterial adhesion and erythrocyte integrity on polycaprolactone nanowire surfaces.RSC advances · 2025Article
- Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility.ACS biomaterials science & engineering · 2025Article
- Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis.International journal of nanomedicine · 2024Article
- Blood Clotting Dissolution in the Presence of a Magnetic Field and Preliminary Study with MG63 Osteoblast-like Cells-Further Developments for Guided Bone Regeneration?Bioengineering (Basel, Switzerland) · 2023Article
- Antithrombogenic properties ofRSC advances · 2021Article
- Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells.Materials science & engineering. C, Materials for biological applications · 2021Article
- Improved hemostatic effects by FeBioactive materials · 2021Article
- Improved hemocompatibility and reduced bacterial adhesion on superhydrophobic titania nanoflower surfaces.Materials science & engineering. C, Materials for biological applications · 2021Article
- In Vitro Investigation of Hemocompatibility of Hydrothermally Treated Titanium and Titanium Alloy Surfaces.ACS omega · 2020Article
- Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers.Journal of biomedical materials research. Part A · 2020Article
- Evaluating Whole Blood ClottingBio-protocol · 2020Article
- Interaction of blood plasma proteins with superhemophobic titania nanotube surfaces.Nanomedicine : nanotechnology, biology, and medicine · 2019Article
- Surface topography of polylactic acid nanofibrous mats: influence on blood compatibility.Journal of materials science. Materials in medicine · 2018Article
- Physical Characterization and Platelet Interactions under Shear Flows of a Novel Thermoset Polyisobutylene-based Co-polymer.ACS applied materials & interfaces · 2015Article
- Improved in vitro blood compatibility of polycaprolactone nanowire surfaces.ACS applied materials & interfaces · 2014Article
- Smooth muscle cell functionality on collagen immobilized polycaprolactone nanowire surfaces.Journal of functional biomaterials · 2014Article
- Anti-thrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics.RSC advances · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tissue integration is an important property when inducing transplant tolerance, however, the hemocompatibility of the biomaterial surface also plays an important role in the ultimate success of the implant. Therefore, in order to induce transplant tolerance, it is critical to understand the interaction of blood components with the material surfaces. In this study, we have investigated the adsorption of key blood serum proteins, in vitro adhesion and activation of platelets and clotting kinetics of whole blood on flat polycaprolactone (PCL) surfaces, nanowire (NW) surfaces and nanofiber (NF) surfaces. Previous studies have shown that polymeric nanostructured surfaces improve cell adhesion, proliferation and viability; however it is unclear how these polymeric nanostructured surfaces interact with the blood and its components. Protein adsorption results indicate that while there were no significant differences in total albumin (ALB) adsorption on PCL, NW and NF surfaces, NW surfaces had higher total fibrinogen (FIB) and immunoglobulin-G (IgG) adsorption compared to NF and PCL surfaces. In contrast, NF surfaces had higher surface FIB and IgG adsorption compared to PCL and NW surfaces. Platelet adhesion and viability studies show more adhesion and clustering of platelets on the NF surfaces as compared to PCL and NW surfaces. Platelet activation studies reveal that NW surfaces have the highest percentage of unactivated platelets, whereas NF surfaces have the highest percentage of fully activated platelets. Whole blood clotting results indicate that NW surfaces maintain an increased amount of free hemoglobin during the clotting process compared to PCL and NF surface, indicating less clotting and slower rate of clotting on their surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.