ArticleAmerican journal of respiratory and critical care medicine2013
Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?Current environmental health reports · 2018Pooled it
- Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review.Environmental research · 2016Pooled it
- Mendelian randomization analysis of arsenic metabolism and pulmonary function within the Hispanic Community Health Study/Study of Latinos.Scientific reports · 2021Trial
- A Versatile In Vitro Quantitative Assay for Macrophage Efferocytosis in Diverse Research Applications.Bio-protocol · 2026Article
- Environmental Arsenic Exposure, Biomarkers and Lung Function in Children from Yaqui Communities in Sonora, Mexico.Journal of xenobiotics · 2025Article
- Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages.Toxicology · 2025Article
- Article
- Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure.Frontiers in molecular biosciences · 2025Article
- Article
- Oral arsenite exposure induces inflammation and apoptosis in pulmonary tissue: acute and chronic evaluation in young and adult mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Inorganic arsenic in seaweed: a fast HPLC-ICP-MS method without coelution of arsenosugars.Analytical and bioanalytical chemistry · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Potential association between arsenic and vitamin D.Frontiers in endocrinology · 2024Article
- Defining high confidence targets of differential CpG methylation in response to in utero arsenic exposure and implications for cancer risk.Toxicology and applied pharmacology · 2024Article
- Pulmonary pathogenesis in a murine model of inhaled arsenical exposure.Archives of toxicology · 2023Article
- Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models.Frontiers in immunology · 2023Article
- Arsenic Induces M2 Macrophage Polarization and Shifts M1/M2 Cytokine Production via Mitophagy.International journal of molecular sciences · 2022Article
- Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma.Chemosphere · 2022Article
- Environmental Substances Associated with Chronic Obstructive Pulmonary Disease-A Scoping Review.International journal of environmental research and public health · 2022Article
- Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
rationaleExposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic.
objectivesTo determine the deleterious effects on lung function that exist among individuals exposed to a high dose of arsenic.
methodsIn 950 individuals who presented with any respiratory symptom among a population-based cohort of 20,033 adults, we evaluated the association between arsenic exposure, measured by well water and urinary arsenic concentrations measured at baseline, and post-bronchodilator-administered pulmonary function assessed during follow-up. MEASUREMENTS AND MAIN
resultsFor every one SD increase in baseline water arsenic exposure, we observed a lower level of FEV1 (-46.5 ml; P < 0.0005) and FVC (-53.1 ml; P < 0.01) in regression models adjusted for age, sex, body mass index, smoking, socioeconomic status, betel nut use, and arsenical skin lesions status. Similar inverse relationships were observed between baseline urinary arsenic and FEV1 (-48.3 ml; P < 0.005) and FVC (-55.2 ml; P < 0.01) in adjusted models. Our analyses also demonstrated a dose-related decrease in lung function with increasing levels of baseline water and urinary arsenic. This association remained significant in never-smokers and individuals without skin lesions, and was stronger in male smokers. Among male smokers and individuals with skin lesions, every one SD increase in water arsenic was related to a significant reduction of FEV1 (-74.4 ml, P < 0.01; and -116.1 ml, P < 0.05) and FVC (-72.8 ml, P = 0.02; and -146.9 ml, P = 0.004), respectively.
conclusionsThis large population-based study confirms that arsenic exposure is associated with impaired lung function and the deleterious effect is evident at low- to moderate-dose range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.