ArticleIET systems biology2013
Architecture-dependent robustness in a class of multiple positive feedback loops.
Article in IET systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- Chromosome 3p deletion leads to extensive genomic alterations in diverse cancers and confers synthetic lethality in uveal melanoma.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Many types of multiple positive feedbacks with each having potentials to generate bistability exist extensively in natural, raising the question of why a particular architecture is present in a cell. In this study, the authors investigate multiple positive feedback loops across three classes: one-loop class, two-loop class and three-loop class, where each class is composed of double positive feedback loop (DPFL) or double negative feedback loop (DNFL) or both. Through large-scale sampling and robustness analysis, the authors find that for a given class, the homogeneous DPFL circuit (i.e. the coupled circuit that is composed of only DPFLs) is more robust than all the other circuits in generating bistable behaviour. In addition, stochastic simulation shows that the low stable state is more robust than the high stable state in homogeneous DPFL whereas the high-stable state is more robust than the low-stable state in homogeneous DNFL circuits. It was argued that this investigation provides insight into the relationship between robustness and network architecture.
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