ArticleFrontiers in oncology2013
Expression and Regulation of the Endogenous Retrovirus 3 in Hodgkin's Lymphoma Cells.
Article in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.Cell · 2025Article
- rs67047829 genotypes of ERV3-1/ZNF117 are associated with lower body mass index in the Polish population.Scientific reports · 2023Article
- HERVs and Cancer-A Comprehensive Review of the Relationship of Human Endogenous Retroviruses and Human Cancers.Biomedicines · 2023Review
- Endogenous Retrovirus RNA Expression Differences between Race, Stage and HPV Status Offer Improved Prognostication among Women with Cervical Cancer.International journal of molecular sciences · 2023Article
- Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications.Journal of medical virology · 2023Review
- HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients.Pathogens (Basel, Switzerland) · 2022Article
- Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers.BMB reports · 2021Article
- Identification of Differentially Expressed Human Endogenous Retrovirus Families in Human Leukemia and Lymphoma Cell Lines and Stem Cells.Frontiers in oncology · 2021Article
- Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer.Genes & genomics · 2020Article
- Identification of human endogenous retrovirus transcripts in Hodgkin Lymphoma cells.Molecular biology reports · 2019Article
- Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.Nature chemical biology · 2018Article
- WebHERV: A Web Server for the Computational Investigation of Gene Expression Associated With Endogenous Retrovirus-Like Sequences.Frontiers in microbiology · 2018Article
- Elevated HERV-K Expression in Soft Tissue Sarcoma Is Associated with Worsened Relapse-Free Survival.Frontiers in microbiology · 2018Article
- Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride.Frontiers in microbiology · 2018Article
- Endogenous Retrovirus 3 - History, Physiology, and Pathology.Frontiers in microbiology · 2017Review
- Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases.BioMed research international · 2017Review
- Stimulation of the hypoxia pathway modulates chemotherapy resistance in Hodgkin's lymphoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- A short treatise concerning a musical approach for the interpretation of gene expression data.Scientific reports · 2015Article
- Decreased expression of endogenous feline leukemia virus in cat lymphomas: a case control study.BMC veterinary research · 2015Article
- Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins.Virology journal · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human endogenous retroviruses (ERV) are an integral part of our genome. Expression of ERV is usually switched off but reactivation of ERV has been observed in varying human diseases including cancer. Recently, reactivation of ERV associated promoters in Hodgkin's lymphoma (HL) cells has been described. Despite relatively good prognosis, not all patients with HL can be cured with the established therapy and this therapy is associated with severe late side effects. Therefore, new targets are required for the development of future treatment strategies. Reactivated ERV might represent such target structures. Therefore, we asked which ERV loci are expressed in HL cells. Using DNA microarray analysis, we found no evidence for a general activation of ERV transcription in HL cells. In contrast, we observed down-regulation of ERV3, an ERV with potential tumor suppressor function, in HL cells in comparison to normal blood cells. Interestingly, ERV3 was also differentially expressed in published DNA microarray data from resting versus cycling B cells. Treatment of HL cells with the histone deacetylase inhibitor vorinostat strongly up-regulated ERV3 expression. In addition, we observed up-regulation in HL cells after treatment with hypoxia-mimetic cobalt(II) chloride. Like vorinostat, cobalt(II) chloride inhibited cell growth of HL cells. Our results suggest that cell cycle inhibition of HL cells is accompanied by up-regulation of ERV3.
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