ArticleBiomedical optics express2013
Multiphoton morpho-functional imaging of healthy colon mucosa, adenomatous polyp and adenocarcinoma.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
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- Novel Pixelwise Co-Registered Hematoxylin-Eosin and Multiphoton Microscopy Image Dataset for Human Colon Lesion Diagnosis.Journal of pathology informatics · 2022Article
- Medical needs related to the endoscopic technology and colonoscopy for colorectal cancer diagnosis.BMC cancer · 2021Article
- Optical biopsy of laryngeal lesions using femtosecond multiphoton microscopy.Biomedical optics express · 2021Article
- Analysis on the Characterization of Multiphoton Microscopy Images for Malignant Neoplastic Colon Lesion Detection under Deep Learning Methods.Journal of pathology informatics · 2021Article
- The Status of Advanced Imaging Techniques for Optical Biopsy of Colonic Polyps.Clinical and translational gastroenterology · 2020Review
- Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma.International journal of biological sciences · 2020Article
- Machine Learning-Based Classification of the Health State of Mice Colon in Cancer Study from Confocal Laser Endomicroscopy.Scientific reports · 2019Article
- Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Spectrum- and time-resolved endogenous multiphoton signals reveal quantitative differentiation of premalignant and malignant gastric mucosa.Biomedical optics express · 2018Article
- Multiphoton microscopy for label-free identification of intramural metastasis in human esophageal squamous cell carcinoma.Biomedical optics express · 2017Article
- Layer-resolved colorectal tissues using nonlinear microscopy.Lasers in medical science · 2015Article
- In vivo nonlinear spectral imaging as a tool to monitor early spectroscopic and metabolic changes in a murine cutaneous squamous cell carcinoma model.Biomedical optics express · 2014Article
- Clinical nonlinear laser imaging of human skin: a review.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-photon spectral resolved imaging was used to image fresh human biopsies of colon tissue and to characterize healthy colon mucosa, adenomatous polyp and adenocarcinoma by means of a morpho-functional analysis. Morphological examination, performed using endogenous tissue fluorescence, discriminated adenomatous and adenocarcinoma tissues from normal mucosa in terms of cellular asymmetry and nucleus-to-cytoplasm ratio. Good agreement was found between multiphoton images and histological examination performed on the same samples. Further characterization, performed by means of spectral-resolved analysis of NADH and FAD fluorescence, demonstrated an altered metabolic activity in both adenomatous and adenocarcinoma tissues compared to healthy mucosa. This morpho-functional approach may represent a powerful method to be used in combination with endoscopy for in vivo optical diagnosis of colon cancer and may be extended to other tissues.
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