ArticleFrontiers in immunology2013
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Sodium nitrite promotes atherosclerosis via IL-1β: Network toxicology and machine learning insights.PloS one · 2026Article
- Effect of Alligator Weed (Animals : an open access journal from MDPI · 2025Article
- Acute Toxicity Assessment, In Vitro Antacid and Cytoprotective Effects of Root Bark Aqueous Extract ofCanadian journal of gastroenterology & hepatology · 2025Article
- Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery.Perioperative medicine (London, England) · 2023Article
- Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Dietary L-citrulline supplementation modulates nitric oxide synthesis and anti-oxidant status of laying hens during summer season.Journal of animal science and biotechnology · 2020Article
- Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice.Journal of atherosclerosis and thrombosis · 2018Article
- A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition.Physiological reports · 2017Article
- Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Therapeutic Efficacy of an ω-3-Fatty Acid-Containing 17-β Estradiol Nano-Delivery System against Experimental Atherosclerosis.PloS one · 2016Article
- Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia.Biochemical pharmacology · 2015Review
- Spotlights on immunological effects of reactive nitrogen species: When inflammation says nitric oxide.World journal of experimental medicine · 2015Review
- Role of sGC-dependent NO signalling and myocardial infarction risk.Journal of molecular medicine (Berlin, Germany) · 2015Review
- Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia.Microvascular research · 2015Article
- The evolution of nitric oxide signalling in vertebrate blood vessels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Restoration of Endothelial Function in Pparα (-/-) Mice by Tempol.PPAR research · 2015Article
- Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis.Oxidative medicine and cellular longevity · 2015Review
- Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice.Scientific reports · 2014Article
- Arginase in the vascular endothelium: friend or foe?Frontiers in immunology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nitric oxide (NO) generated through L-arginine metabolism by endothelial nitric oxide synthase (eNOS) is an important regulator of the vessel wall. Dysregulation of this system has been implicated in various pathological vascular conditions, including atherosclerosis, angiogenesis, arteriogenesis, neointimal hyperplasia, and pulmonary hypertension. The pathophysiology involves a decreased bioavailability of NO within the vessel wall by competitive utilization of L-arginine by arginase and "eNOS uncoupling." Generation of NO through reduction of nitrate and nitrite represents an alternative pathway that may be utilized to increase the bioavailability of NO within the vessel wall. We review the therapeutic potential of the nitrate/nitrite/NO pathway in vascular dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.