Evidence map›Paper›PMID 23847549›Full record

ArticleFrontiers in physiology2013

Association of heart rate variability and inflammatory response in patients with cardiovascular diseases: current strengths and limitations.

Vasilios Papaioannou, Ioannis Pneumatikos, Nikos Maglaveras

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05911724 (Diagnostic and Prognostic Roles of Inflammatory Biomarkers in Coronary Heart Disease and Heart Failure Patients Treated With Empagliflozin.), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05911724 completedstarted 2023, after this paper: background citation

Diagnostic and Prognostic Roles of Inflammatory Biomarkers in Coronary Heart Disease and Heart Failure Patients Treated With Empagliflozin.

Ran2023Enrolled180Registered outcomes7Posted comparisons0ConditionsHeart Failure, Stable AnginaArmsCAD-Empagliflozin 10 mg once daily for 6 months before the beginning of the study, Group I Healthy, HF-Empagliflozin 10 mg once daily for 6 months before the beginning of the study
PMID 29066452PMID 18160340PMID 30942129PMID 24766981other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  9. Relationship Between Physical Activity and Autonomic Responses in Adults with Type 2 Diabetes.International journal of environmental research and public health · 2025
    Observational
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  14. Calciphylaxis: A Mimic of Vasculitis.Mediterranean journal of rheumatology · 2025
    Article
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  19. Polyunsaturated Fatty Acid EAB-277Frontiers in veterinary science · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vasilios PapaioannouIntensive Care Unit, Alexandroupolis General Hospital, Democritus University of Thrace Alexandroupolis, Greece.
Ioannis Pneumatikos
Nikos Maglaveras
Democritus University of Thrace · GRAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many experimental and clinical studies have confirmed a continuous cross-talk between both sympathetic and parasympathetic branches of autonomic nervous system and inflammatory response, in different clinical scenarios. In cardiovascular diseases, inflammation has been proven to play a pivotal role in disease progression, pathogenesis and resolution. A few clinical studies have assessed the possible inter-relation between neuro-autonomic output, estimated with heart rate variability analysis, which is the variability of R-R in the electrocardiogram, and different inflammatory biomarkers, in patients suffering from stable or unstable coronary artery disease (CAD) and heart failure. Moreover, different indices derived from heart rate signals' processing, have been proven to correlate strongly with severity of heart disease and predict final outcome. In this review article we will summarize major findings from different investigators, evaluating neuro-immunological interactions through heart rate variability analysis, in different groups of cardiovascular patients. We suggest that markers originating from variability analysis of heart rate signals seem to be related to inflammatory biomarkers. However, a lot of open questions remain to be addressed, regarding the existence of a true association between heart rate variability and autonomic nervous system output or its adoption for risk stratification and therapeutic monitoring at the bedside. Finally, potential therapeutic implications will be discussed, leading to autonomic balance restoration in relation with inflammatory control.

Indexed as

autonomic nervous systemcardiovascular diseasecoronary artery diseaseheart rate variabilityinflammationmortality

Identifiers

PMID23847549
PMCPMC3706751
OpenAlexW2090939247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.