ArticleFrontiers in physiology2013
Leptin expression affects metabolic rate in zebrafish embryos (D. rerio).
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- A chromosome-level genome assembly for the Silkie chicken resolves complete sequences for key chicken metabolic, reproductive, and immunity genes.Communications biology · 2023Article
- Roles of leptin in initiation of acquired growth hormone resistance and control of metabolism in rainbow trout.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Changes of DNA Methylation Pattern in Metabolic Pathways Induced by High-Carbohydrate Diet Contribute to Hyperglycemia and Fat Deposition in Grass Carp (Frontiers in endocrinology · 2020Article
- Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling.Scientific reports · 2019Article
- Article
- Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation.International journal of molecular sciences · 2018Article
- Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia.Frontiers in endocrinology · 2018Article
- Comparative Physiology of Energy Metabolism: Fishing for Endocrine Signals in the Early Vertebrate Pool.Frontiers in endocrinology · 2017Review
- On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin.Frontiers in endocrinology · 2017Article
- Signal transduction mechanism for glucagon-inducedInternational journal of biological sciences · 2016Article
- The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge.Frontiers in neuroscience · 2016Review
- Leptin Genes in Blunt Snout Bream: Cloning, Phylogeny and Expression Correlated to Gonads Development.International journal of molecular sciences · 2015Article
- Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity.PPAR research · 2015Review
- Comparative endocrinology of leptin: assessing function in a phylogenetic context.General and comparative endocrinology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We used antisense morpholino oligonucleotide technology to knockdown leptin-(A) gene expression in developing zebrafish embryos and measured its effects on metabolic rate and cardiovascular function. Using two indicators of metabolic rate, oxygen consumption was significantly lower in leptin morphants early in development [<48 hours post-fertilization (hpf)], while acid production was significantly lower in morphants later in development (>48 hpf). Oxygen utilization rates in <48 hpf embryos and acid production in 72 hpf embryos could be rescued to that of wildtype embryos by recombinant leptin coinjected with antisense morpholino. Leptin is established to influence metabolic rate in mammals, and these data suggest leptin signaling also influences metabolic rate in fishes.
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Registered trials
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