ArticleFrontiers in human neuroscience2013
Long-term changes in cognitive bias and coping response as a result of chronic unpredictable stress during adolescence.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Cognitive Bias Under Adverse and Rewarding Conditions: A Systematic Review of Rodent Studies.Frontiers in behavioral neuroscience · 2020Pooled it
- Adolescent stress exposure induces persistent, sex-specific cognitive deficits.Neurobiology of learning and memory · 2025Article
- Social media positive feedback and its impact on adolescents' health risk behaviors: the chain mediation role of cognitive bias and emotions.BMC public health · 2025Article
- A repeated measures cognitive affective bias test in rats: comparison with forced swim test.Psychopharmacology · 2023Article
- The Emotion Regulation Mechanism in Neurotic Individuals: The Potential Role of Mindfulness and Cognitive Bias.International journal of environmental research and public health · 2023Article
- Potential resilience treatments for orangutans (Animal welfare (South Mimms, England) · 2023Article
- Early-life stress affects Mongolian gerbil interactions with conspecific vocalizations in a sex-specific manner.Frontiers in behavioral neuroscience · 2023Article
- Sex and age differences in cognitive bias and neural activation in response to cognitive bias testing.Neurobiology of stress · 2022Article
- Cumulative lifetime stressor exposure assessed by the STRAIN predicts economic ambiguity aversion.Nature communications · 2022Article
- Application of Cognitive Bias Testing in Neuropsychiatric Disorders: A Mini-Review Based on Animal Studies.Frontiers in behavioral neuroscience · 2022Review
- The Effects of Rosiglitazone on Task Specific Anxiety-Like Behavior and Novelty Seeking in a Model of Chronic Adolescent Unpredictable Stress.Frontiers in behavioral neuroscience · 2022Article
- Chronic unpredictable stress during adolescence protects against adult traumatic brain injury-induced affective and cognitive deficits.Brain research · 2021Article
- Adult Male Rats Show Resilience to Adolescent Bisphenol A Effects on Hormonal and Behavioral Responses While Co-Exposure With Hop Extracts Supports Synergistic Actions.Frontiers in toxicology · 2021Article
- Acute stress imposed during adolescence yields heightened anxiety in Sprague Dawley rats that persists into adulthood: Sex differences and potential involvement of the Medial Amygdala.Brain research · 2019Article
- Effects of early and later life environmental enrichment and personality on attention bias in pigs (Sus scrofa domesticus).Animal cognition · 2019Article
- Pharmacologically-induced stress has minimal impact on judgement and attention biases in sheep.Scientific reports · 2019Article
- Long-term impact of chronic variable stress in adolescence versus adulthood.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Developmental history and stress responsiveness are related to response inhibition, but not judgement bias, in a cohort of European starlings (Sturnus vulgaris).Animal cognition · 2019Article
- Density-dependent changes in neophobia and stress-coping styles in the world's oldest farmed fish.Royal Society open science · 2018Article
- Environmental complexity buffers against stress-induced negative judgement bias in female chickens.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals that experience adverse events in early life often have life-long changes to their physiology and behavior. Long-term effects of stress during early life have been studied extensively, but less attention has been given to the consequences of negative experiences solely during the adolescent phase. Adolescence is a particularly sensitive period of life when regulation of the glucocorticoid "stress" hormone response matures and specific regions in the brain undergo considerable change. Aversive experiences during this time might, therefore, be expected to generate long-term consequences for the adult phenotype. Here we investigated the long-term effects of exposure to chronic unpredictable stress during adolescence on adult decision-making, coping response, cognitive bias, and exploratory behavior in rats. Rats exposed to chronic unpredictable stress (e.g., isolation, crowding, cage tilt) were compared to control animals that were maintained in standard, predictable conditions throughout development. Unpredictable stress during adolescence resulted in a suite of long-term behavioral and cognitive changes including a negative cognitive bias [F (1, 12) = 5.000, P < 0.05], altered coping response [T (1, 14) = 2.216, P = 0.04], and accelerated decision-making [T (1, 14) = 3.245, P = 0.01]. Exposure to chronic stress during adolescence also caused a short-term increase in boldness behaviors; in a novel object test 15 days after the last stressor, animals exposed to chronic unpredictable stress had decreased latencies to leave a familiar shelter and approach a novel object [T (1, 14) = 2.240, P = 0.04; T (1, 14) = 2.419, P = 0.03, respectively]. The results showed that stress during adolescence has long-term impacts on behavior and cognition that affect the interpretation of ambiguous stimuli, behavioral response to adverse events, and how animals make decisions.
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