ArticleInvestigative ophthalmology & visual science2013
Theoretical analysis of vascular regulatory mechanisms contributing to retinal blood flow autoregulation.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
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- Characteristics of Retinal Oxygen Kinetics and Blood Flow in Myopia of Different Degrees.Investigative ophthalmology & visual science · 2025Article
- Three-dimensional spatiotemporal analysis for the assessment of retinal capillary perfusion using a clinical OCT system.Scientific reports · 2025Article
- Impact of Vascular Network Structure Heterogeneity on Retinal Tissue Oxygenation.La matematica · 2025Article
- Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina.Investigative ophthalmology & visual science · 2025Article
- Predicting the impact of retinal vessel density on retinal vessel and tissue oxygenation using a theoretical model.Mathematical biosciences · 2024Article
- Potential measurement error from vessel reflex and multiple light paths in dual-wavelength retinal oximetry.Acta ophthalmologica · 2024Article
- Linking Vascular Structure and Function: Image-Based Virtual Populations of the Retina.Investigative ophthalmology & visual science · 2024Article
- Evaluation of the effect of hemodynamic factors on retinal microcirculation by using 3D confocal image-based computational fluid dynamics.Frontiers in bioengineering and biotechnology · 2024Article
- Variability in Capillary Perfusion Is Increased in Regions of Retinal Ischemia Due to Branch Retinal Vein Occlusion.Investigative ophthalmology & visual science · 2023Article
- Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation.Mathematical biosciences · 2023Article
- Subretinal fluid disturbs the retinal venous blood flow in central serous chorioretinopathy.Scientific reports · 2022Article
- A multi-scale/multi-physics model for the theoretical study of the vascular configuration of retinal capillary plexuses based on OCTA data.Mathematical medicine and biology : a journal of the IMA · 2022Article
- Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models.Pharmaceutical research · 2021Review
- Article
- Physics-based modeling of Age-related Macular Degeneration-A theoretical approach to quantify retinal and choroidal contributions to macular oxygenation.Mathematical biosciences · 2021Article
- Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina.Mathematical biosciences · 2020Article
- Ocular blood flow as a clinical observation: Value, limitations and data analysis.Progress in retinal and eye research · 2020Article
- Neurodegenerative Disorders of the Eye and of the Brain: A Perspective on Their Fluid-Dynamical Connections and the Potential of Mechanism-Driven Modeling.Frontiers in neuroscience · 2020Review
- Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo study whether impaired retinal autoregulation is a risk factor for glaucoma, the relationship between vascular regulatory mechanisms and glaucoma progression needs to be investigated. In this study, a vascular wall mechanics model is used to predict the relative importance of regulatory mechanisms in achieving retinal autoregulation.
methodsResistance vessels are assumed to respond to changes in pressure, shear stress, carbon dioxide (CO2), and the downstream metabolic state communicated via conducted responses. Model parameters governing wall tension are fit to pressure and diameter data from porcine retinal arterioles. The autoregulation pressure range for control and elevated levels of IOP is predicted.
resultsThe factor by which flow changes as the blood pressure exiting the central retinal artery is varied between 28 and 40 mm Hg is used to indicate the degree of autoregulation (1 indicates perfect autoregulation). In the presence of only the myogenic response mechanism, the factor is 2.06. In the presence of the myogenic and CO2 responses, the factor is 1.22. The combination of myogenic, shear, CO2, and metabolic responses yields the best autoregulation (factor of 1.10).
conclusionsModel results are compared with flow and pressure data from multiple patient studies, and the combined effects of the metabolic and CO2 responses are predicted to be critical for achieving retinal autoregulation. When IOP is elevated, the model predicts a decrease in the autoregulation range toward low perfusion pressure, which is consistent with observations that glaucoma is associated with decreased perfusion pressure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.