ArticleInvestigative ophthalmology & visual science2013
Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopy.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Biomechanical changes after repeated collagen cross-linking on human corneas assessed in vitro using scanning acoustic microscopy.Investigative ophthalmology & visual science · 2014Trial
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- Assessment of choroidal vascularity and thickness after corneal crosslinking treatment in keratoconus.BMC ophthalmology · 2026Article
- Clinical Outcomes of Repeated Corneal Crosslinking for Progressive Keratoconus After Failure of Primary Procedure; Safety and Efficacy at 12-Month Follow-Up.Ophthalmology and therapy · 2025Article
- Changes in retinal vessel and retinal layer thickness after cross-linking in keratoconus via swept-source OCT angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021Review
- Assessment of the changes in corneal biomechanical properties after collagen cross-linking in patients with keratoconus.Journal of current ophthalmology · 2019Article
- An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas.Investigative ophthalmology & visual science · 2018Article
- Conventional vs. pulsed-light accelerated corneal collagen cross-linking for the treatment of progressive keratoconus: 12-month results from a prospective study.Experimental and therapeutic medicine · 2017Article
- Effect of corneal collagen crosslinking on subsequent deep anterior lamellar keratoplasty (DALK) in keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- Conventional Versus Accelerated Collagen Cross-Linking for Keratoconus: A Comparison of Visual, Refractive, Topographic and Biomechanical Outcomes.The open ophthalmology journal · 2017Article
- Recent Innovations in Collagen Corneal Cross-linking; a Mini Review.The open ophthalmology journal · 2017Article
- In Vivo Corneal Biomechanical Properties with Corneal Visualization Scheimpflug Technology in Chinese Population.BioMed research international · 2016Article
- Standard versus accelerated riboflavin-ultraviolet corneal collagen crosslinking: Resistance against enzymatic digestion.Journal of cataract and refractive surgery · 2015Article
- Is accelerated corneal collagen cross-linking for keratoconus the way forward? Yes.Eye (London, England) · 2014Article
- Repeated corneal crosslinking for progressive keratoconus: efficiency and safety.Therapeutic advances in ophthalmologyReview
- Corneal collagen cross-linking: a review.Journal of optometryReview
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9 authors.
Funding
Abstract
purposeTo assess and compare changes in the biomechanical properties of the cornea following different corneal collagen cross-linking protocols using scanning acoustic microscopy (SAM).
methodsTen donor human corneal pairs were divided into two groups consisting of five corneal pairs in each group. In group A, five corneas were treated with low-fluence (370 nm, 3 mW/cm(2)) cross-linking (CXL) for 30 minutes. In group B, five corneas were treated with high-fluence (370 nm, 9 mW/cm(2)) CXL for 10 minutes. The contralateral control corneas in both groups had similar treatment but without ultraviolet A. The biomechanical properties of all corneas were tested using SAM.
resultsIn group A, the mean speed of sound in the treated corneas was 1677.38 ± 10.70 ms(-1) anteriorly and 1603.90 ± 9.82 ms(-1) posteriorly, while it was 1595.23 ± 9.66 ms(-1) anteriorly and 1577.13 ± 8.16 ms(-1) posteriorly in the control corneas. In group B, the mean speed of sound of the treated corneas was 1665.06 ± 9.54 ms(-1) anteriorly and 1589.89 ± 9.73 ms(-1) posteriorly, while it was 1583.55 ± 8.22 ms(-1) anteriorly and 1565.46 ± 8.13 ms(-1) posteriorly in the untreated control corneas. The increase in stiffness between the cross-linked and control corneas in both groups was by a factor of 1.051×.
conclusionsSAM successfully detected changes in the corneal stiffness after application of collagen cross-linking. A higher speed-of-sound value was found in the treated corneas when compared with the controls. No significant difference was found in corneal stiffness between the corneas cross-linked with low- and high-intensity protocols.
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