ArticleBMJ open2013
Long-term change in alcohol-consumption status and variations in fibrinogen levels: the coronary artery risk development in young adults (CARDIA) study.
Article in BMJ open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Association between change in alcohol use reported during routine healthcare screening and change in subsequent hospitalization: A retrospective cohort study.Addiction (Abingdon, England) · 2025Article
- Effect of Beer Consumption on Methylation and Redox Metabolism.Physiological research · 2022Article
- Article
- Cannabis Use and Markers of Systemic Inflammation: The Coronary Artery Risk Development in Young Adults Study.The American journal of medicine · 2019Article
- Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study.BMJ (Clinical research ed.) · 2016Article
- Markers of inflammation and mortality in a cohort of patients with alcohol dependence.Medicine · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine long-term associations between change in alcohol-consumption status and cessation of alcohol use, and fibrinogen levels in a large, young, biracial cohort.
designAnalysis of covariance models were used to analyse participants within the Coronary Artery Risk Development in Young Adults Study (CARDIA) cohort who had fibrinogen and alcohol use data at year 7 (1992-1993; ages 25-37) and year 20 examinations.
setting4 urban US cities. PATIENTS: 2520 men and women within the CARDIA cohort.
main outcome measures13-year changes in alcohol use related to changes in fibrinogen.
resultsOver 13 years, mean fibrinogen increased by 71 vs 70 mg/dL (p=NS) in black men (BM) versus white men (WM), and 78 vs 68 mg/dL (p<0.05) in black women (BW) versus white women (WW), respectively. Compared with never-drinkers, there were smaller longitudinal increases in fibrinogen for BM, BW and WW (but a larger increase in WM) who became or stayed drinkers, after multivariable adjustment. For BM, WM and WW, fibrinogen increased the most among persons who quit drinking over 13 years (p<0.001 for WM (fibrinogen increase=86.5 (7.1) (mean (SE))), compared with never-drinkers (fibrinogen increase=53.1 (5.4)).
conclusionsIn this young cohort, compared with the participants who never drank, those who became/stayed drinkers had smaller increases, while those who quit drinking had the highest increase in fibrinogen over 13 years of follow-up. The results provide a novel insight into the mechanism for the established protective effect of moderate alcohol intake on cardiovascular disease outcomes.
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Registered trials
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