ArticleThe Plant cell2013
MADS domain transcription factors mediate short-range DNA looping that is essential for target gene expression in Arabidopsis.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Analysis of the arabidopsis REM gene family predicts functions during flower development.Annals of botany · 2014Pooled it
- Article
- SPOROCYTELESS/NOZZLE cooperates with MADS-domain transcription factors to regulate an auxin-dependent network controlling Megaspore-Mother-Cell differentiation.Nature communications · 2025Article
- AP1 is a pioneer transcription factor that programmes cell fate through MADS-domain protein tetramerisation.Genome biology · 2025Article
- Genome-Wide Association Study Reveals Candidate Genes Regulating Plant Height and First-Branch Height inInternational journal of molecular sciences · 2025Article
- Structural insights into CDF1 accumulation on the CONSTANS promoter via a plant-specific DNA-binding domain.Nature plants · 2025Article
- Auxin response factor 10 insensitive to miR160regulation induces apospory-like phenotypes iniScience · 2024Article
- SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development.The Plant cell · 2024Article
- Reflections on the ABC model of flower development.The Plant cell · 2024Review
- Genome-wide identification of the B3 transcription factor family in pepper (Capsicum annuum) and expression patterns during fruit ripening.Scientific reports · 2024Article
- The Origin of Floral Quartet Formation-Ancient Exon Duplications Shaped the Evolution of MIKC-type MADS-domain Transcription Factor Interactions.Molecular biology and evolution · 2023Article
- Floral Homeotic Factors: A Question of Specificity.Plants (Basel, Switzerland) · 2023Review
- BELL1 interacts with CRABS CLAW and INNER NO OUTER to regulate ovule and seed development in pomegranate.Plant physiology · 2023Article
- RNA polymerase efficiently transcribes through DNA-scaffolded, cooperative bacteriophage repressor complexes.FEBS letters · 2022Article
- Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops.Nucleic acids research · 2022Article
- VviAGL11 self-regulates and targets hormone- and secondary metabolism-related genes during seed development.Horticulture research · 2022Article
- The intervening domain is required for DNA-binding and functional identity of plant MADS transcription factors.Nature communications · 2021Article
- Plant 3D genomics: the exploration and application of chromatin organization.The New phytologist · 2021Review
- Endophytic Fungi: From Symbiosis to Secondary Metabolite Communications or Vice Versa?Frontiers in plant science · 2021Review
- Understanding 3D Genome Organization and Its Effect on Transcriptional Gene Regulation Under Environmental Stress in Plant: A Chromatin Perspective.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
MADS domain transcription factors are key regulators of eukaryotic development. In plants, the homeotic MIKC MADS factors that regulate floral organ identity have been studied in great detail. Based on genetic and protein-protein interaction studies, a floral quartet model was proposed that describes how these MADS domain proteins assemble into higher order complexes to regulate their target genes. However, despite the attractiveness of this model and its general acceptance in the literature, solid in vivo proof has never been provided. To gain deeper insight into the mechanisms of transcriptional regulation by MADS domain factors, we studied how SEEDSTICK (STK) and SEPALLATA3 (SEP3) directly regulate the expression of the reproductive meristem gene family transcription factor-encoding gene VERDANDI (VDD). Our data show that STK-SEP3 dimers can induce loop formation in the VDD promoter by binding to two nearby CC(A/T)6GG (CArG) boxes and that this is essential for promoter activity. Our in vivo data show that the size and position of this loop, determined by the choice of CArG element usage, is essential for correct expression. Our studies provide solid in vivo evidence for the floral quartet model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.