ArticleStem cells (Dayton, Ohio)2013
Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis.
Article in Stem cells (Dayton, Ohio), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 115 citations in OpenAlex.
- Trial
- Heparanase 2 (Hpa2) protects the exocrine pancreas from damages of Western diet and pancreatic cancer.International journal of biological sciences · 2026Article
- Islet Cell Replacement and Regeneration for Type 1 Diabetes: Current Developments and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025Review
- Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells.Bioactive materials · 2024Article
- Molecular Basis of Pancreatic Neuroendocrine Tumors.International journal of molecular sciences · 2024Review
- Pancreatic Differentiation of Oral Minor Salivary Gland Stem Cells.Stem cell reviews and reports · 2024Article
- Generation ofRegenerative therapy · 2024Review
- Cell transplantation-based regenerative medicine in liver diseases.Stem cell reports · 2023Review
- A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans.NPJ Regenerative medicine · 2023Article
- Article
- Regenerative medicine: current research and perspective in pediatric surgery.Pediatric surgery international · 2023Review
- Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models.Pathology international · 2022Review
- Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes.Frontiers in cell and developmental biology · 2022Article
- Patch grafting, strategies for transplantation of organoids into solid organs such as liver.Biomaterials · 2021Article
- A Case of Myoepithelial Hamartoma: Morphological Variation Supported by OCT4 Expression.Case reports in gastrointestinal medicine · 2021Article
- Molecular heterogeneity in intrahepatic cholangiocarcinoma.World journal of hepatology · 2020Review
- Peribiliary glands pathology in a large series of end-stage alcohol-related liver disease.Virchows Archiv : an international journal of pathology · 2020Article
- Stem cell therapy: a potential for the perils of pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Review
- Asbestos and Intrahepatic Cholangiocarcinoma.Cells · 2020Review
- Article
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Authors and funding
15 authors at 7 institutions in 2 countries.
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Abstract
Peribiliary glands (PBGs) in bile duct walls, and pancreatic duct glands (PDGs) associated with pancreatic ducts, in humans of all ages, contain a continuous, ramifying network of cells in overlapping maturational lineages. We show that proximal (PBGs)-to-distal (PDGs) maturational lineages start near the duodenum with cells expressing markers of pluripotency (NANOG, OCT4, and SOX2), proliferation (Ki67), self-replication (SALL4), and early hepato-pancreatic commitment (SOX9, SOX17, PDX1, and LGR5), transitioning to PDG cells with no expression of pluripotency or self-replication markers, maintenance of pancreatic genes (PDX1), and expression of markers of pancreatic endocrine maturation (NGN3, MUC6, and insulin). Radial-axis lineages start in PBGs near the ducts' fibromuscular layers with stem cells and end at the ducts' lumens with cells devoid of stem cell traits and positive for pancreatic endocrine genes. Biliary tree-derived cells behaved as stem cells in culture under expansion conditions, culture plastic and serum-free Kubota's Medium, proliferating for months as undifferentiated cells, whereas pancreas-derived cells underwent only approximately 8-10 divisions, then partially differentiated towards an islet fate. Biliary tree-derived cells proved precursors of pancreas' committed progenitors. Both could be driven by three-dimensional conditions, islet-derived matrix components and a serum-free, hormonally defined medium for an islet fate (HDM-P), to form spheroids with ultrastructural, electrophysiological and functional characteristics of neoislets, including glucose regulatability. Implantation of these neoislets into epididymal fat pads of immunocompromised mice, chemically rendered diabetic, resulted in secretion of human C-peptide, regulatable by glucose, and able to alleviate hyperglycemia in hosts. The biliary tree-derived stem cells and their connections to pancreatic committed progenitors constitute a biological framework for life-long pancreatic organogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.