ArticleMolecules (Basel, Switzerland)2013
Flexibilisquinone, a new anti-inflammatory quinone from the cultured soft coral Sinularia flexibilis.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Cembranoids from the cultured soft coralRSC advances · 2026Article
- The application and sustainable development of coral in traditional medicine and its chemical composition, pharmacology, toxicology, and clinical research.Frontiers in pharmacology · 2023Review
- Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential.Marine drugs · 2022Review
- Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years.Acta pharmaceutica Sinica. B · 2022Review
- Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral GenusMarine drugs · 2021Review
- New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft CoralMarine drugs · 2020Article
- Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model.Marine drugs · 2018Article
- Bioactive Prenyl- and Terpenyl-Quinones/Hydroquinones of Marine OriginMarine drugs · 2018Review
- Cembranoid-Related Metabolites and Biological Activities from the Soft CoralMarine drugs · 2018Article
- Review
- Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells.Marine drugs · 2016Article
- Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.Journal of natural products · 2016Article
- New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris.Marine drugs · 2015Article
- Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Excavatolide B Isolated from the Culture-Type Formosan Gorgonian Briareum excavatum.Marine drugs · 2015Article
- Marine low molecular weight natural products as potential cancer preventive compounds.Marine drugs · 2014Review
- Corals and their potential applications to integrative medicine.Evidence-based complementary and alternative medicine : eCAM · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.