ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Orthostatic hypotension and incident heart failure in community-dwelling older adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- The Prevalence of Orthostatic Hypotension: A Systematic Review and Meta-Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Pooled it
- Orthostatic hypotension and the risk of atrial fibrillation and other cardiovascular diseases: An updated meta-analysis of prospective cohort studies.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Orthostatic Hypotension in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) Blood Pressure Trial: Prevalence, Incidence, and Prognostic Significance.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- Profile and predictors of mortality among free-living elderly subjects: a community-based prospective cohort study from Kerala, India.BMJ public health · 2026Article
- Prevalence of orthostatic hypotension and associated factors among older people with hypertension in Northern Ethiopia.BMC geriatrics · 2024Article
- Sex-related differences in the clinical presentation of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Role of Orthostatic Hypotension in the Development of Dementia in People With and Without Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Association of orthostatic blood pressure response with incident heart failure: The Framingham Heart Study.PloS one · 2022Observational
- Initial orthostatic hypotension and orthostatic intolerance symptom prevalence in older adults: A systematic review.International Journal of Cardiology. Hypertension · 2021Review
- Efficacy and Safety of Ivabradine in an Elderly Patient with Heart Failure with Reduced Ejection Fraction.Clinical drug investigation · 2021Article
- Systolic blood pressure postural changes variability is associated with greater dementia risk.Neurology · 2020Article
- Article
- Prevalence of Orthostatic Hypotension and the Distribution of Pressure Variation in the Longitudinal Study of Adult Health.Arquivos brasileiros de cardiologia · 2020Article
- Health and Functional Determinants of Orthostatic Hypotension in Geriatric Ward Patients: A Retrospective Cross Sectional Cohort Study.The journal of nutrition, health & aging · 2019Article
- Diagnosing orthostatic hypotension with continuous and interval blood pressure measurement devices.Journal of human hypertension · 2018Article
- Risk Factors for Orthostatic Hypotension: Differences Between Elderly Men and Women.American journal of hypertension · 2018Article
- Standing orthostatic blood pressure measurements cannot be replaced by sitting measurements.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Observational
- Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study.PLoS medicine · 2016Article
- Heart failure and orthostatic hypotension.Heart failure reviews · 2016Review
- Arterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo examine the association of orthostatic hypotension with incident heart failure (HF) in older adults.
methodsOf the 5,273 community-dwelling adults aged 65 years and older free of baseline prevalent HF in the Cardiovascular Health Study, 937 (18%) had orthostatic hypotension, defined as ≥20 mmHg drop in systolic or ≥10 mmHg drop in diastolic blood pressure from supine to standing position at 3 minutes. Of the 937, 184 (20%) had symptoms of dizziness upon standing and were considered to have symptomatic orthostatic hypotension. Propensity scores for orthostatic hypotension were estimated for each of the 5,273 participants and were used to assemble a cohort of 3,510 participants (883 participants with and 2,627 participants without orthostatic hypotension) who were balanced on 40 baseline characteristics. Cox regression models were used to estimate the association of orthostatic hypotension with centrally adjudicated incident HF and other outcomes during 13 years of follow-up.
resultsParticipants (n = 3,510) had a mean (±standard deviation) age of 74 (±6) years, 58% were women, and 15% nonwhite. Incident HF occurred in 25% and 21% of matched participants with and without orthostatic hypotension, respectively (hazard ratio, 1.24; 95% confidence interval, 1.06-1.45; p = .007). Among matched participants, hazard ratios for incident HF associated with symptomatic (n = 173) and asymptomatic (n = 710) orthostatic hypotension were 1.57 (95% confidence interval, 1.16-2.11; p = .003) and 1.17 (95% confidence interval, 0.99-1.39; p = .069), respectively.
conclusionsCommunity-dwelling older adults with orthostatic hypotension have higher independent risk of developing new-onset HF, which appeared to be more pronounced in those with symptomatic orthostatic hypotension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.