ArticlePlant reproduction2013
Computational identification of conserved microRNAs and their putative targets in the Hypericum perforatum L. flower transcriptome.
Article in Plant reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Paradigm shift in apomixis research: Targeting mutants with elements of apomixis in sexual crops.Planta · 2026Review
- Genome-wide identification and characterization of DUF789 genes in cotton: implications for fibre development.BMC plant biology · 2025Article
- Recent Progress on Plant Apomixis for Genetic Improvement.International journal of molecular sciences · 2024Review
- Decoding drought resilience: a comprehensive exploration of the cotton Eceriferum (CER) gene family and its role in stress adaptation.BMC plant biology · 2024Article
- Apomixis: oh, what a tangled web we have!Planta · 2023Review
- MicroRNAs in Medicinal Plants.International journal of molecular sciences · 2022Review
- The emerging role of small RNAs in ovule development, a kind of magic.Plant reproduction · 2021Review
- Antiproliferative Effects of St. John's Wort, Its Derivatives, and OtherInternational journal of molecular sciences · 2020Review
- Article
- Characterization and discovery of miRNA and miRNA targets from apomictic and sexual genotypes of Eragrostis curvula.BMC genomics · 2019Article
- Small RNA-seq reveals novel regulatory components for apomixis in Paspalum notatum.BMC genomics · 2019Article
- Annotation and Expression of IDN2-like and FDM-like Genes in Sexual and AposporousPlants (Basel, Switzerland) · 2019Article
- Ovule Gene Expression Analysis in Sexual and Aposporous ApomicticFrontiers in plant science · 2019Article
- miR394 Acts as a Negative Regulator ofFrontiers in plant science · 2018Article
- Diplosporous development in Boehmeria tricuspis: Insights from de novo transcriptome assembly and comprehensive expression profiling.Scientific reports · 2017Article
- Computational prediction of miRNAs and their targets in Phaseolus vulgaris using simple sequence repeat signatures.BMC plant biology · 2015Article
- De novo sequencing of the Hypericum perforatum L. flower transcriptome to identify potential genes that are related to plant reproduction sensu lato.BMC genomics · 2015Article
- The genetic control of apomixis: asexual seed formation.Genetics · 2014Review
- Harnessing plant reproduction for crop improvement: an introduction to the special issue.Plant reproduction · 2013Article
- Apomixis in plant reproduction: a novel perspective on an old dilemma.Plant reproduction · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) have recently emerged as important regulators of gene expression in plants. Many miRNA families and their targets have been extensively studied in model species and major crops. We have characterized mature miRNAs along with their precursors and potential targets in Hypericum to generate a comprehensive list of conserved miRNA families and to investigate the regulatory role of selected miRNAs in biological processes that occur in the flower. St. John's wort (Hypericum perforatum L., 2n = 4x = 32), a medicinal plant that produces pharmaceutically important metabolites with therapeutic activities, was chosen because it is regarded as an attractive model system for the study of apomixis. A computational in silico prediction of structure, in combination with an in vitro validation, allowed us to identify 7 pre-miRNAs, including miR156, miR166, miR390, miR394, miR396, and miR414. We demonstrated that H. perforatum flowers share highly conserved miRNAs and that these miRNAs potentially target dozens of genes with a wide range of molecular functions, including metabolism, response to stress, flower development, and plant reproduction. Our analysis paves the way toward identifying flower-specific miRNAs that may differentiate the sexual and apomictic reproductive pathways.
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