ArticleParasitology research2013
Coinfection with Clonorchis sinensis modulates murine host response against Trichinella spiralis infection.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Co-infection and interaction of enteric pathogens in acute diarrhea among children under five years: a large-scale multicenter observational study from China.Infectious diseases of poverty · 2025Observational
- Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis.BMC veterinary research · 2024Article
- Pumpkin seeds (Cucurbita pepo subsp. ovifera) decoction promotes Trichinella spiralis expulsion during intestinal phase via "Weep and Sweep" mechanism.Scientific reports · 2024Article
- Dynamics of co-infection in fish: A review of pathogen-host interaction and clinical outcome.Fish and shellfish immunology reports · 2023Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Regulation of human THP-1 macrophage polarization by Trichinella spiralis.Parasitology research · 2021Article
- Galectin-Receptor Interactions Regulates Cardiac Pathology Caused byFrontiers in immunology · 2021Article
- Exposure time determines the protective effect of Trichinella spiralis on experimental colitis.Microbial pathogenesis · 2020Article
- Infection against infection: parasite antagonism against parasites, viruses and bacteria.Infectious diseases of poverty · 2019Review
- Type 2 immunity in tissue repair and fibrosis.Nature reviews. Immunology · 2018Review
- Immune Cell Responses and Cytokine Profile in Intestines of Mice Infected withFrontiers in microbiology · 2017Article
- The impact of co-infections on fish: a review.Veterinary research · 2016Review
- Alpha-tocopherol transfer protein gene inhibition enhances the acquired immune response during malaria infection in mice.Parasitology research · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concomitant infections of different species of parasites are common in the field. Infection with one parasite species likely triggers host responses that may influence the subsequent infection of another species and alter disease outcomes. So far, the majority of studies have focused on single species parasite infection, and the mechanisms of protection induced by the first parasite infection against the secondary infection remain poorly defined. In this study, we assess the impact of trematode Clonorchis sinensis infection on the course of another tissue nematode Trichinella spiralis challenge. We observed that mice with preexisting C. sinensis infection had lower worm burden of intestinal T. spiralis than those infected with T. spiralis alone; mice with preexisting C. sinensis also had severe enteric histopathological changes and higher counts of intestinal Paneth cells in responses to T. spiralis challenge. The mRNA levels of interleukin (IL)-4, IL-10, IL-13, and tumor necrosis factor (TNF)-α from the small intestine and spleen of the different groups were analyzed using quantitative real-time polymerase chain reaction. Compared with that in mice infected with T. spiralis alone, the mRNA expression of IL-13 was significantly increased in the small intestine tissues and IL-4, IL-13, and TNF-α were significantly increased in the spleen tissues in the dually infected mice. Our findings suggest that a "preexisting" trematode infection of C. sinensis is a factor which contributes to reducing the establishment of T. spiralis adult worms in the small intestine.
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