ArticleRespiratory medicine2013
Fixed ratio or lower limit of normal as cut-off value for FEV1/VC: an outcome study.
Article in Respiratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of comorbidities and prognosis in patients with COPD diagnosed with the fixed ratio and the lower limit of normal: a systematic review and meta-analysis.Respiratory research · 2020Pooled it
- Health status and prognosis of COPD patients in relation to the FEVNPJ primary care respiratory medicine · 2026Article
- Reply to Neder, to OgataAmerican journal of respiratory and critical care medicine · 2024Article
- COPD Diagnosis: Time for Disruption.Journal of clinical medicine · 2021Review
- The ratio FEVClinical physiology and functional imaging · 2021Article
- Joint Indian Chest Society-National College of Chest Physicians (India) guidelines for spirometry.Lung India : official organ of Indian Chest Society · 2019Article
- Diagnosis of Chronic Obstructive Pulmonary Disease: Breathing New Life into an Old Debate.Annals of the American Thoracic Society · 2018Article
- The Efficiency Index (EFFi), based on volumetric capnography, may allow for simple diagnosis and grading of COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- The prognostic significance of lung function in stable heart failure outpatients.Clinical cardiology · 2017Article
- Incidence of airflow limitation in subjects 65-100 years of age.The European respiratory journal · 2016Article
- Vital capacity and COPD: the Swedish CArdioPulmonary bioImage Study (SCAPIS).International journal of chronic obstructive pulmonary disease · 2016Article
- Comment on: Wollmer P, Engström G. Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV1/VC: An outcome study. Respiratory Medicine (2013) 107, 1460-1462.: Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV1/VC.Respiratory medicine · 2015Article
- Comorbidity of heart failure and chronic obstructive pulmonary disease: more than coincidence.Current heart failure reports · 2014Review
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
There is no consensus on the appropriate cut-off level for the ratio between forced expiratory volume and vital capacity (FEV(1)/VC) for the diagnosis of chronic obstructive pulmonary disease (COPD). Application of a fixed ratio of 0.7 carries the risk of false positive diagnoses in elderly subjects and false negative diagnoses in younger subjects. The use of the lower limit of normal (LLN) of an individually predicted value should eliminate this problem. There is insufficient information about the outcome of elderly subjects with an FEV(1)/VC < 0.7 but above the LLN. We report lung function (spirometry and lung clearance index, LCI), mortality and risk of cardiac events in relation to FEV(1)/VC in a population-based sample of men examined at age 55 years. We stratified subjects as having FEV(1)/VC ≥ 0.7 (N), <0.7 but > LLN (FR+) and <0.7 and <LLN (FR+LLN+). Hazard ratio for death was 1, 1.33 (0.94-1.9) and 1.71 (1.3-2.2), respectively, when adjusted for smoking and a number of cardiovascular risk factors. In contrast, there was no increase in the corrected hazard ratio for cardiac events. FEV(1) progressively declined and LCI increased from N to FR+ and FR+LLN+. Subjects with FEV(1)/VC ratio below 0.7 but above the lower limit of normal form an intermediate group with respect to lung function impairment and mortality rates. Careful evaluation of patient history and extended lung function testing may be warranted in subjects with FEV(1)/VC < 0.7 but above the lower limit of normal.
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