ArticleChinese journal of natural medicines2013
A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.
Article in Chinese journal of natural medicines, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Medicinal compounds and biotechnology of Amaryllidaceae alkaloids inFrontiers in plant science · 2025Review
- Chemical Characterization and Cytotoxic and Antioxidant Activity Evaluation of the Ethanol Extract from the Bulbs ofMolecules (Basel, Switzerland) · 2023Article
- Alkaloid Profiling, Anti-Enzymatic and Antiproliferative Activity of the Endemic Chilean AmaryllidaceaeMetabolites · 2022Article
- Chemistry and Biological Activity of Alkaloids from the GenusMolecules (Basel, Switzerland) · 2020Review
- Isolation of Three Lycorine Type Alkaloids fromMetabolites · 2020Article
- Amaryllidaceae Alkaloids of Belladine-Type fromBiomolecules · 2020Article
- Amaryllidaceae Alkaloids of Different Structural Types fromPlants (Basel, Switzerland) · 2020Article
- Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species.Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata.
methodsThe chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A.
resultsOne new homolycorine-type alkaloid 2α-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2α-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6α-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained.
conclusionAlkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively.
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