ArticleVirus research2013
MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis.
Article in Virus research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Human Metapneumovirus (HMPV): Advances in Diagnosis, Molecular Epidemiology, and Clinical Impact of an Underrecognized Respiratory Virus.Diagnostics (Basel, Switzerland) · 2026Review
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- Interferon Epsilon-Mediated Antiviral Activity Against Human Metapneumovirus and Respiratory Syncytial Virus.Vaccines · 2024Article
- Role of human metapneumovirus glycoprotein G in modulation of immune responses.Frontiers in immunology · 2022Article
- Exchange Protein Directly Activated by cAMP 2 Enhances Respiratory Syncytial Virus-Induced Pulmonary Disease in Mice.Frontiers in immunology · 2021Article
- The role of M2-2 PDZ-binding motifs in pulmonary innate immune responses to human metapneumovirus.Journal of medical virology · 2020Article
- Prophylactic and therapeutic approaches for human metapneumovirus.Virusdisease · 2018Review
- Human Metapneumovirus: Mechanisms and Molecular Targets Used by the Virus to Avoid the Immune System.Frontiers in immunology · 2018Review
- Human metapneumovirus - what we know now.F1000Research · 2018Review
- Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model.Pathogens (Basel, Switzerland) · 2015Review
- Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus.The Journal of general virology · 2015Article
- Human metapneumovirus: review of an important respiratory pathogen.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2014Review
- Human metapneumovirus M2-2 protein inhibits innate immune response in monocyte-derived dendritic cells.PloS one · 2014Article
Corrections and comments
- Erratum issuedGarafalo, Roberto P [corrected to Garofalo, Roberto P]
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Human metapneumovirus (hMPV) is a common cause of lung and airway infections in infants and young children. Recently, we and others have shown that hMPV infection induces Toll-like receptor (TLR)-dependent cellular signaling. However, the contribution of TLR-mediated signaling in host defenses against pulmonary hMPV infection and associated disease pathogenesis has not been elucidated. In this study, mice deficient in MyD88, a common adaptor of TLRs, was used to investigate the contribution of TLRs to in vivo pulmonary response to hMPV infection. MyD88(-/-) mice have significantly reduced pulmonary inflammation and associated disease compared with wild-type (WT) C57BL/6 mice after intranasal infection with hMPV. hMPV-induced cytokines and chemokines in bronchoalveolar lavage fluid (BALF) and isolated lung conventional dendritic cells (cDC) are also significantly impaired by MyD88 deletion. In addition, we found that MyD88 is required for the recruitment of DC, T cells, and other immune cells to the lungs, and for the functional regulation of DC and T cells in response to hMPV infection. Taken together, our data indicate that MyD88-mediated pathways are essential for the pulmonary immune and pathogenic responses to this viral pathogen.
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Registered trials
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