ArticleMethods (San Diego, Calif.)2013
Development of a method to isolate circulating tumor cells using mesenchymal-based capture.
Article in Methods (San Diego, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Circulating tumour cells as a window into lethality in prostate cancer.Nature reviews. Urology · 2026Review
- Unique Cohorts of Salivary Gland Cancer Cells as anJournal of maxillofacial and oral surgery · 2024Article
- Genetic analysis of heterogeneous subsets of circulating tumour cells from high grade serous ovarian carcinoma patients.Scientific reports · 2023Article
- Nano-Theranostics for the Sensing, Imaging and Therapy of Prostate Cancers.Frontiers in chemistry · 2022Review
- Review
- Liquid Biopsies in Lung Cancer: Four Emerging Technologies and Potential Clinical Applications.Cancers · 2019Article
- Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Circulating tumor cells in prostate cancer: Precision diagnosis and therapy.Oncology letters · 2017Article
- Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration.The American journal of pathology · 2017Article
- Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer.Prostate cancer and prostatic diseases · 2016Article
- Clinical and biological significance of circulating tumor cells in cancer.Molecular oncology · 2016Review
- Circulating Tumor Cell Composition in Renal Cell Carcinoma.PloS one · 2016Article
- Clinical Utility of Circulating Tumor Cells in Advanced Prostate Cancer.Current oncology reports · 2016Review
- When Prostate Cancer Circulates in the Bloodstream.Diagnostics (Basel, Switzerland) · 2015Review
- Androgen receptor expression in circulating tumour cells from castration-resistant prostate cancer patients treated with novel endocrine agents.British journal of cancer · 2015Article
- Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Using circulating tumor cells to inform on prostate cancer biology and clinical utility.Critical reviews in clinical laboratory sciences · 2015Review
- Quantitative characterization of androgen receptor protein expression and cellular localization in circulating tumor cells from patients with metastatic castration-resistant prostate cancer.Journal of translational medicine · 2014Article
- Role of circulating tumor cells and cancer stem cells in hepatocellular carcinoma.Hepatology international · 2014Article
- Circulating tumour cells-monitoring treatment response in prostate cancer.Nature reviews. Clinical oncology · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Epithelial tumor cells can become mesenchymal cells and vice versa via phenotypic transitions, a process known as epithelial plasticity. We postulate that during the process of metastasis, circulating tumor cells (CTCs) lose their epithelial phenotype and acquire a mesenchymal phenotype that may not be sufficiently captured by existing epithelial-based CTC technologies. We report here on the development of a novel CTC capture method, based on the biology of epithelial plasticity, which isolates cells based on OB-cadherin cell surface expression. Using this mesenchymal-based assay, OB-cadherin cellular events are detectable in men with metastatic prostate cancer and are less common in healthy volunteers. This method may complement existing epithelial-based methods and may be particularly useful in patients with bone metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.