ArticleBMC genomics2013
Genomics analysis of potassium channel genes in songbirds reveals molecular specializations of brain circuits for the maintenance and production of learned vocalizations.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.Ecology and evolution · 2026Article
- Alpha-synuclein overexpression reduces neural activity within a basal ganglia vocal nucleus in a zebra finch model.PloS one · 2026Article
- Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes.eLife · 2023Article
- Light-induced shifts in opsin gene expression in the four-eyed fishFrontiers in neuroscience · 2022Article
- Resurgent NaNature communications · 2021Article
- Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches.Advanced genetics (Hoboken, N.J.) · 2021Article
- Molecular specializations of deep cortical layer analogs in songbirds.Scientific reports · 2020Article
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- Exploring the molecular basis of neuronal excitability in a vocal learner.BMC genomics · 2019Article
- Seasonal changes in the song control nuclei of the Rufous-bellied Thrush, Turdus rufiventris (Oscine, Passeriformes, and Turdidae).Journal of experimental zoology. Part B, Molecular and developmental evolution · 2019Article
- Copy Number Variation Mapping and Genomic Variation of Autochthonous and Commercial Turkey Populations.Frontiers in genetics · 2019Article
- A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism.BMC genetics · 2018Article
- Curation of microarray oligonucleotides and corresponding ESTs/cDNAs used for gene expression analysis in zebra finches.BMC research notes · 2018Article
- The constitutive differential transcriptome of a brain circuit for vocal learning.BMC genomics · 2018Article
- Long-term sensitization training inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Automatic Construction of Predictive Neuron Models through Large Scale Assimilation of Electrophysiological Data.Scientific reports · 2016Article
- Dynamic gene expression in the song system of zebra finches during the song learning period.Developmental neurobiology · 2015Article
- Living without DAT: Loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles).Scientific reports · 2015Article
- Neural transcriptome reveals molecular mechanisms for temporal control of vocalization across multiple timescales.BMC genomics · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA fundamental question in molecular neurobiology is how genes that determine basic neuronal properties shape the functional organization of brain circuits underlying complex learned behaviors. Given the growing availability of complete vertebrate genomes, comparative genomics represents a promising approach to address this question. Here we used genomics and molecular approaches to study how ion channel genes influence the properties of the brain circuitry that regulates birdsong, a learned vocal behavior with important similarities to human speech acquisition. We focused on potassium (K-)Channels, which are major determinants of neuronal cell excitability.
resultsWe identified 107 K-Channel finch genes, including 6 novel genes common to non-mammalian vertebrate lineages. Twenty human genes are absent in songbirds, birds, or sauropsids, or unique to mammals, suggesting K-Channel properties may be lineage-specific. We also identified specific family members with insertions/deletions and/or high dN/dS ratios compared to chicken, a non-vocal learner. In situ hybridization revealed that while most K-Channel genes are broadly expressed in the brain, a subset is selectively expressed in song nuclei, representing molecular specializations of the vocal circuitry.
conclusionsTogether, these findings shed new light on genes that may regulate biophysical and excitable properties of the song circuitry, identify potential targets for the manipulation of the song system, and reveal genomic specializations that may relate to the emergence of vocal learning and associated brain areas in birds.
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