ArticleBMC neuroscience2013
Abnormal activity of default mode network in GERD patients.
Article in BMC neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Verbal Creativity Is Correlated With the Dynamic Reconfiguration of Brain Networks in the Resting State.Frontiers in psychology · 2019Article
- Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.Brain : a journal of neurology · 2018Article
- Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA.Cell & bioscience · 2014Article
- The brain-esophagus axis in subjects with and without obesity assessed by esophageal acid perfusion and functional brain imaging.Annals of gastroenterologyArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormal processing of esophageal sensation at the level of the central nervous system has been proven to be involved in gastroesophageal reflux disease (GERD). However, most studies were focused on the possible functions of perceptual processing related network during task status, little attention has been paid to default mode network, which has been manifested to be important in the pathogenesis of many diseases. In our study, we compared the brain activity characteristic in GERD patients with the healthy subjects (HS) at baseline, looking for whether activities of default mode network were abnormal in GERD patients and attempting to identify their possible roles in GERD. In present study, fractional amplitude of low-frequency fluctuation was adopted to detect the brain activities at baseline. Group-level analyses were conducted by one-sample t test within groups (voxel thresholds were p<0.001 and cluster level>42, corrected P<0.05) and independent-samples t test between groups (p<0.01 and cluster level>90, corrected P<0.05) using SPM5.
resultsThe predominant activity area in both groups mainly located in default mode network such as medial superior frontal gyrus, precuneus, posterior cingulate gyrus, etc. However, the activities of precuneus and posterior cingulate gyrus were significantly lower in GERD patients than those in the HS.
conclusionsThe activities of precuneus and posterior cingulate gyrus of default mode network in GERD patients were significantly lower compared to the HS, suggesting abnormal activities of brain regions in default mode network may be involved in pathophysiology of GERD symptom generation.
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