ArticlePulmonary medicine2013
Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance.
Article in Pulmonary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Diffusing capacity in chronic obstructive pulmonary disease assessment: A meta-analysis.Chronic respiratory diseasePooled it
- Use of Impulse Oscillometry in Patients with Chronic Obstructive Pulmonary Disease.Thoracic research and practice · 2026Article
- The Impact of Age and Disease Entity on Small Airway Dysfunction in Obstructive Airway Diseases.International journal of chronic obstructive pulmonary disease · 2025Article
- Beyond the Spirometry: New Diagnostic Modalities in Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2025Article
- Quantitative analysis of lung function and airway remodeling using ventilation/perfusion single photon emission tomography/computed tomography and HRCT in patients with chronic obstructive pulmonary disease and asthma.Annals of nuclear medicine · 2023Article
- Comparative assessment of small airway dysfunction by impulse oscillometry and spirometry in chronic obstructive pulmonary disease and asthma with and without fixed airflow obstruction.Frontiers in medicine · 2023Article
- Single-nucleotide polymorphisms in the sulfatase-modifying factor 1 gene are associated with lung function and COPD.ERJ open research · 2022Article
- The Efficiency Index (EFFi), based on volumetric capnography, may allow for simple diagnosis and grading of COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation.Respiratory research · 2017Article
- Impulse oscillometry system as an alternative diagnostic method for chronic obstructive pulmonary disease.Medicine · 2017Observational
- Clinical Roles of Lung Volumes Detected by Body Plethysmography and Helium Dilution in Asthmatic Patients: A Correlation and Diagnosis Analysis.Scientific reports · 2017Article
- Effects of combination therapy indacaterol/glycopyrronium versus tiotropium on moderate to severe COPD: evaluation of impulse oscillometry and exacerbation rate.Multidisciplinary respiratory medicine · 2017Article
- Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease.International journal of chronic obstructive pulmonary disease · 2017Article
- The measurement of lung volumes using body plethysmography and helium dilution methods in COPD patients: a correlation and diagnosis analysis.Scientific reports · 2016Article
- Heliox-Driven Nebulization Has a Positive Effect on the Lung Function in Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease Rat Model.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Bronchodilator response of advanced lung function parameters depending on COPD severity.International journal of chronic obstructive pulmonary disease · 2016Article
- The differential effects of inspiratory, expiratory, and combined resistive breathing on healthy lung.International journal of chronic obstructive pulmonary disease · 2016Article
- Grading obstructive lung disease using tomographic pulmonary scintigraphy in patients with chronic obstructive pulmonary disease (COPD) and long-term smokers.Annals of nuclear medicine · 2015Article
- A new approach to assess COPD by identifying lung function break-points.International journal of chronic obstructive pulmonary disease · 2015Article
- The Immediate Pulmonary Disease Pattern following Exposure to High Concentrations of Chlorine Gas.Pulmonary medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classification of COPD into different GOLD stages is based on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) but has shown to be of limited value. The aim of the study was to relate spirometry values to more advanced measures of lung function in COPD patients compared to healthy smokers. The lung function of 65 COPD patients and 34 healthy smokers was investigated using flow-volume spirometry, body plethysmography, single breath helium dilution with CO-diffusion, and impulse oscillometry. All lung function parameters, measured by body plethysmography, CO-diffusion, and impulse oscillometry, were increasingly affected through increasing GOLD stage but did not correlate with FEV1 within any GOLD stage. In contrast, they correlated fairly well with FVC%p, FEV1/FVC, and inspiratory capacity. Residual volume (RV) measured by body plethysmography increased through GOLD stages, while RV measured by helium dilution decreased. The difference between these RV provided valuable additional information and correlated with most other lung function parameters measured by body plethysmography and CO-diffusion. Airway resistance measured by body plethysmography and impulse oscillometry correlated within COPD stages. Different lung function parameters are of importance in COPD, and a thorough patient characterization is important to understand the disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.