ArticlePloS one2013
Enrichment of elevated plasma F2t-isoprostane levels in individuals with autism who are stratified by presence of gastrointestinal dysfunction.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03426826 (Dynamics of Gut Microbiomes in Autism Spectrum Disorder), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dynamics of Gut Microbiomes in Autism Spectrum Disorder (ASD) Symptoms
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Prenatal air pollution, maternal immune activation, and autism spectrum disorder.Environment international · 2023Article
- Treatment of Autism Spectrum Disorders by Mitochondrial-targeted Drug: Future of Neurological Diseases Therapeutics.Current neuropharmacology · 2023Review
- Oxidative Stress in Autism Spectrum Disorder-Current Progress of Mechanisms and Biomarkers.Frontiers in psychiatry · 2022Review
- Progressions on the Coexistence of Neuronal and Glial Precursor Cells in the Cerebral Ventricular Zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Cyclopentenone Prostaglandins: Biologically Active Lipid Mediators Targeting Inflammation.Frontiers in physiology · 2021Review
- Oxidative Stress in Autism Spectrum Disorder.Molecular neurobiology · 2020Review
- Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder.Environment international · 2019Article
- Article
- Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2018Review
- Depletion of Stercobilin in Fecal Matter from a Mouse Model of Autism Spectrum Disorders.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- The joint effect of air pollution exposure and copy number variation on risk for autism.Autism research : official journal of the International Society for Autism Research · 2017Article
- Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.PloS one · 2017Article
- Article
- The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders.BMC medicine · 2015Article
- The isoprostanes--25 years later.Biochimica et biophysica acta · 2015Review
- Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.Molecular autism · 2015Article
- Autism Spectrum Disorder: Defining Dimensions and Subgroups.Current developmental disorders reports · 2014Article
- Subclinical inflammatory status in Rett syndrome.Mediators of inflammation · 2014Article
- Biomarkers in autism.Frontiers in psychiatry · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
Etiology is unknown in the majority of individuals with autism spectrum disorder (ASD). One strategy to investigate pathogenesis is to stratify this heterogeneous disorder based on a prominent phenotypic feature that enriches for homogeneity within population strata. Co-occurring gastrointestinal dysfunction (GID) characterizes a subset of children with ASD. Our current objective was to investigate a potential pathophysiological measure to test the hypothesis that children with both ASD and GID have a more severe metabolic dysfunction than children with ASD-only, given that the highly metabolically active brain and gastrointestinal system may additively contribute measurable impairment. Plasma levels of F2t-Isoprostanes (F2-IsoPs), a gold standard biomarker of oxidative stress, were measured in 87 children in four groups: ASD-GID, ASD-only, GID-only and Unaffected. F2-IsoP levels were elevated in all 3 clinical groups compared to the Unaffected group, with the ASD-GID group significantly elevated above the ASD-only group (mean, SD in pg/mg: ASD-GID 53.6, 24.4; ASD-only 36.5, 13.3; p = 0.007). Adjusting for age, sex, and triglyceride levels, F2-IsoP levels remained significantly different between study groups, with a moderate effect size of η(p)(2) = 0.187 (p = 0.001). Elevation in peripheral oxidative stress is consistent with, and may contribute to, the more severe functional impairments in the ASD-GID group. With unique medical, metabolic, and behavioral features in children with ASD-GID, the present findings serve as a compelling rationale for both individualized approaches to clinical care and integrated studies of biomarker enrichment in ASD subgroups that may better address the complex etiology of ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.