ArticlePloS one2013
Cortical hand bone porosity and its association with distal radius fracture in middle aged and elderly women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Efficacy and safety of denosumab compared to bisphosphonates in improving bone strength in postmenopausal osteoporosis: a systematic review.Singapore medical journal · 2019Pooled it
- Evaluation of trabecular bone score in patients with a distal radius fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Technologies for assessment of bone reflecting bone strength and bone mineral density in elderly women: an update.Women's health (London, England) · 2016Article
- Bone strength and management of postmenopausal fracture risk with antiresorptive therapies: considerations for women's health practice.International journal of women's health · 2016Review
- Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats.Experimental gerontology · 2015Article
- Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Cortical bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.Clinical endocrinology · 2015Article
- DXR-derived cortical porosity predicts fragility fractures.BoneKEy reports · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveReduced bone mineral density (BMD), assessed by Dual Energy X-ray absorptiometry (DXA), is a well-known risk factor for fragility fracture. A large proportion of patients with fracture have only slightly reduced BMD. Assessment of other bone structure features than BMD may improve identification of individuals at increased fracture risk. Digital X-ray radiogrammetry (DXR), which is a feasible tool for measurement of metacarpal cortical bone density, also gives an estimate of cortical bone porosity. Our primary aim was to explore the association between cortical porosity in the hand assessed by DXR and distal radius fracture.
methodsThis case-control study included 123 women >50 years with distal radius fracture, and 170 controls. DXR was used to measure metacarpal BMD (DXR-BMD), cortical porosity (DXR-porosity), thickness (DXR-CT) and bone width (DXR-W) of the hand. Femoral neck BMD was measured by DXA.
resultsThe fracture group had a statistically significant lower DXR-BMD (0.492 vs. 0.524 g/cm(2) p<0.001), higher cortical DXR-porosity (0.01256 vs. 0.01093, p<0.001), less DXR-CT (0.148 vs. 0.161 cm, p<0.001) and lower femoral neck DXA-BMD (0.789 vs. 0.844 g/cm(2), p = 0.001) than the controls. In logistic regression analysis adjusted for age, a significant association with distal radius fracture (OR, 95% CI) was found for body mass index (0.930, 0.880-0.983), DXA-BMD (0.996, 0.995-0.999), DXR-BMD (0.990, 0.985-0.998), DXR-porosity (1.468, 1.278-1.687) and DXR-CT (0.997, 0.996-0.999). In an adjusted model, DXR-porosity remained the only variable associated with distal radius fracture (1.415, 1.194-1.677).
conclusionDXR derived porosity is associated with fracture at distal radius and might be a sensitive marker for skeletal fragility.
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