ArticlePloS one2013
Proteomic evaluation of acquired enamel pellicle during in vivo formation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 111 citations in OpenAlex.
- Article
- Article
- Preservation Strategies for Interfacial Integrity in Restorative Dentistry: A Non-Comprehensive Literature Review.Journal of functional biomaterials · 2025Review
- Acquired pellicle engineering: a fascinating approach to prevent demineralization.Journal of applied oral science : revista FOB · 2025Review
- Positive Role of Saliva in the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Histatins, proangiogenic molecules with therapeutic implications in regenerative medicine.iScience · 2024Review
- Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate onInternational journal of molecular sciences · 2024Article
- Salivary Proteins in Human Acquired Enamel Pellicle (AEP) on Eroded and Uneroded Teeth in Patients with Gastro-Oesophageal Reflux Disease (GORD).Dentistry journal · 2024Article
- Can the combination of proanthocyanidin and vitamin E or palm oil effectively protect enamel against in vitro erosive and abrasive challenges?Journal of applied oral science : revista FOB · 2024Article
- Amyloid Fibrils Produced byInternational journal of molecular sciences · 2023Article
- The composition of the dental pellicle: an updated literature review.Frontiers in oral health · 2023Review
- Caries Management-The Role of Surface Interactions in De- and Remineralization-Processes.Journal of clinical medicine · 2022Review
- Pellicle modification with natural bioproducts: Influence on tooth color under erosive conditions.European journal of oral sciences · 2022Article
- A Mass Spectrometric Approach to the Proteomic Profiling of theJournal of veterinary dentistry · 2022Article
- Article
- Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study.Pharmaceutics · 2022Article
- Analysing Complex Oral Protein Samples: Complete Workflow and Case Analysis of Salivary Pellicles.Journal of clinical medicine · 2021Review
- Preventive Applications of Polyphenols in Dentistry-A Review.International journal of molecular sciences · 2021Review
- Evaluating protein binding specificity of titanium surfaces through mass spectrometry-based proteomics.Clinical oral investigations · 2021Article
- The salivary pellicle on dental biomaterials.Colloids and surfaces. B, Biointerfaces · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Acquired enamel pellicle (AEP) is a protein film that forms on the enamel surface of teeth by selective adsorption of proteins and peptides present in the mouth. This protein film forms the interface between enamel and the damage oral biofilm, which modulates the attachment of bacteria found in oral biofilm. The overall goal of this study was to gain insight into the biological formation of the human in vivo AEP. This study hypothesized that AEP is created by the formation of successive protein layers, which consist of initial binding to enamel and subsequent protein-protein interactions. This hypothesis was examined by observing quantitative and qualitative changes in pellicle composition during the first two hours of AEP formation in the oral cavity. Quantitative mass spectrometry approaches were used to generate an AEP protein profile for each time-point studied. Relative proteomic quantification was carried out for the 50 proteins observed in all four time-points. Notably, the abundance of important salivary proteins, such as histatin 1, decrease with increasing of the AEP formation, while other essential proteins such as statherin showed constant relative abundance in all time-points. In summary, this is the first study that investigates the dynamic process to the AEP formation by using proteomic approaches. Our data demonstrated that there are significant qualitative and quantitative proteome changes during the AEP formation, which in turn will likely impact the development of oral biofilms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.