ArticlePloS one2013
Impact of multiple cardiovascular risk factors on carotid intima-media thickness and elasticity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Six-month longitudinal tracking of arterial stiffness and blood pressure in young adults following SARS-CoV-2 infection.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Carotid Atherosclerosis Predicts Blood Pressure Control in Patients With Hypertension: The Campania Salute Network Registry.Journal of the American Heart Association · 2022Article
- Relationship between Pulse Wave Velocity and Cardiovascular Biomarkers in Patients with Risk Factors.Arquivos brasileiros de cardiologia · 2020Article
- Decreased GFR and its joint association with type 2 diabetes and hypertension with prevalence and severity of carotid plaque in a community population in China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Burden of carotid artery atherosclerosis in Chinese adults: Implications for future risk of cardiovascular diseases.European journal of preventive cardiology · 2017Article
- Impact of Cardiovascular Risk Factors on Carotid Intima-Media Thickness and Degree of Severity: A Cross-Sectional Study.PloS one · 2015Article
- The Relationship of Metabolic Syndrome with Stress, Coronary Heart Disease and Pulmonary Function--An Occupational Cohort-Based Study.PloS one · 2015Article
- A neurodegenerative vascular burden index and the impact on cognition.Frontiers in aging neuroscience · 2014Article
- Detection of subclinical atherosclerosis in asymptomatic subjects using ultrasound radiofrequency-tracking technology.PloS one · 2014Article
- Association of traditional cardiovascular risk factors with carotid atherosclerosis among adults at a teaching hospital in south-western Nigeria.Cardiovascular journal of AfricaArticle
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Authors and funding
9 authors.
Funding
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Abstract
backgroundCarotid intima-media thickness (IMT) and elasticity have been shown to be independent predictors of cardiovascular disease (CVD). Cardiovascular risk factors (CVRFs) includes hypertension, dyslipidemia, diabetes, overweight and smoking. The objective was to investigate whether the clustering of three or more components of CVRFs has a greater impact on carotid IMT and elasticity than individual components of CVRFs.
methodsOne hundred and seventy-three participants without clinical CVD were classified as the multiple CVRFs patients with three or more CVRFs (n = 55) and control group with two or less CVRFs (n = 118). Carotid IMT and elastic modulus were measured by B-mode ultrasound and vessel texture matching method (VTMM), respectively.
resultsThe multiple CVRFs conferred a disproportionate increase in carotid IMT (43%, p<0.0001) and elastic modulus (60%, p<0.0001), compared with control group. Multiple regression models, which included age, gender, as well as each individual component of CVRFs as continuous variables, showed that multiple CVRFs was an independent determinant of both IMT (p = 0.042) and elasticity (p = 0.008). In the analysis of variance adjusted with age, subjects with single, double, and multiple CVRFs, increased by 8.1%, 42.2%, and 66% for IMT, 54.6%, 94.3%, and 125.2% for elastic modulus, respectively, compared to subjects without CVRFs.
conclusionsThe clustering of multiple CVRFs has a greater impact on carotid IMT and elasticity than individual components of CVRFs. This suggests that the components of CVRFs interact to synergistically impact carotid IMT and elasticity.
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