ArticlePloS one2013
Yield of two consecutive sputum specimens for the effective diagnosis of pulmonary tuberculosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Authors' response.The Indian journal of medical research · 2025Article
- Enhancing the diagnostic scope of the PathoDetectTM MTB RIF & INH assay: A call for inclusive evaluation.The Indian journal of medical research · 2025Article
- Pulmonary Tuberculosis Diagnosis Using an Intelligent Microscopy Scanner and Image Recognition Model for Improved Acid-Fast Bacilli Detection in Smears.Microorganisms · 2024Article
- Evaluation of an AI-Based TB AFB Smear Screening System for Laboratory Diagnosis on Routine Practice.Sensors (Basel, Switzerland) · 2022Article
- Prevalence of Mycobacterium tuberculosis in Sputum and Reported Symptoms Among Clinic Attendees Compared With a Community Survey in Rural South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Same-day Smear Method Compared with Conventional Sputum Method for Diagnosing Pulmonary Tuberculosis.Cureus · 2018Article
- Comparison ofJournal of medical science and clinical research · 2017Article
- Diagnostic performance of smear microscopy and incremental yield of Xpert in detection of pulmonary tuberculosis in Rwanda.BMC infectious diseases · 2016Article
- Educational intervention for collecting sputum for tuberculosis: a quasi-experimental study.Revista latino-americana de enfermagem · 2016Article
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Authors and funding
7 authors.
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Abstract
backgroundFrom long instances, it is debatable whether three sputum specimens are required for the diagnosis of pulmonary tuberculosis (TB) or TB can be diagnosed effectively using two consecutive sputum specimens. This study was set out to evaluate the significance of examining multiple sputum specimens in diagnosis of TB.
methodsWe retrospectively reviewed the acid-fast bacillus (AFB) smear and culture results of three consecutive days' sputum specimens from 413 confirmed TB patients which were detected as part of a larger active case finding study in Dhaka Central Jail, the largest correctional facility in Bangladesh.
resultsAFB was detected from 81% (n = 334) patients, of which 89% (n = 297) were diagnosed from the first and additional 9% (n = 30) were from the second sputum specimen. M. tuberculosis growth was observed for 406 patients and 85% (n = 343) were obtained from the first sputum and additional 10% (n = 42) were from the second one. The third specimen didn't show significant additional diagnostic value for the detection of AFB by microscopy or growth of the M. tuberculosis.
conclusionsWe concluded from our study results that examining two consecutive sputum specimens is sufficient enough for the effective diagnosis of TB. It can also decrease the laboratory workload and hence improve the quality of work in settings with high TB burden like Bangladesh.
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