ArticlePloS one2013
Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cell Therapy of Vascular and Neuropathic Complications of Diabetes: Can We Avoid Limb Amputation?International journal of molecular sciences · 2023Article
- Cell senescence alters responses of porcine trabecular meshwork cells to shear stress.Frontiers in cell and developmental biology · 2022Article
- Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway.Journal of cellular and molecular medicine · 2021Article
- Effects of shear stress on differentiation of stem cells into endothelial cells.World journal of stem cells · 2021Review
- Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia.International journal of molecular sciences · 2020Review
- Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel.Heart and vessels · 2020Article
- Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype.Frontiers in cardiovascular medicine · 2020Article
- Vascularization in tissue engineering: fundamentals and state-of-art.Progress in biomedical engineering (Bristol, England) · 2020Article
- IFN-I Mediates Dysfunction of Endothelial Progenitor Cells in Atherosclerosis of Systemic Lupus Erythematosus.Frontiers in immunology · 2020Review
- Shear Stress Triggers Angiogenesis of Late Endothelial Progenitor Cells via the PTEN/Akt/GTPCH/BH4 Pathway.Stem cells international · 2020Article
- Mechanoresponse of stem cells for vascular repair.World journal of stem cells · 2019Review
- Mechanical influences on cardiovascular differentiation and disease modeling.Experimental cell research · 2019Review
- Whole-Transcriptome Sequencing: a Powerful Tool for Vascular Tissue Engineering and Endothelial Mechanobiology.High-throughput · 2018Review
- Corneal epithelial cells exposed to shear stress show altered cytoskeleton and migratory behaviour.PloS one · 2017Article
- Repeat remote ischaemic pre-conditioning for improved cardiovascular function in humans: A systematic review.International journal of cardiology. Heart & vasculature · 2016Review
- Uremic Toxicity of Advanced Glycation End Products in CKD.Journal of the American Society of Nephrology : JASN · 2016Review
- Influence of mechanical stimulation on human dermal fibroblasts derived from different body sites.International journal of clinical and experimental medicine · 2015Article
- Accelerating in situ endothelialisation of cardiovascular bypass grafts.International journal of molecular sciences · 2014Review
- Influence of airway wall compliance on epithelial cell injury and adhesion during interfacial flows.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Mechanoregulation of Angiogenesis in Wound Healing.Advances in wound care · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated that endothelial progenitor cells (EPCs), in particular late EPCs, play important roles in endothelial maintenance and repair. Recent evidence has revealed shear stress as a key regulator for EPC differentiation. However, the underlying mechanisms regulating the shear stress-induced EPC differentiation have not been understood completely. The present study was undertaken to further investigate the effects of shear stress on the late EPC differentiation, and to elucidate the signal mechanism involved. METHODOLOGY/PRINCIPAL FINDING: In vitro and in vivo assays revealed that cytoskeletal remodeling was involved in the shear stress-upregulated expression of endothelial markers vWF and CD31 in late EPCs, with subsequently increased in vivo reendothelialization after arterial injury. Moreover, shear stress activated several mechanosensitive molecules including integrin β1, Ras, ERK1/2, paxillin and FAK, which were all involved in both cytoskeletal rearrangement and cell differentiation in response to shear stress in late EPCs. CONCLUSIONS/SIGNIFICANCE: Shear stress is a key regulator for late EPC differentiation into endothelial cells, which is important for vascular repair, and the cytoskeletal rearrangement mediated by the activation of the cascade of integrin β1, Ras, ERK1/2, paxillin and FAK is crucial in this process.
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Registered trials
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