ArticlePloS one2013
Livestock-associated methicillin and multidrug resistant Staphylococcus aureus is present among industrial, not antibiotic-free livestock operation workers in North Carolina.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Methicillin-resistantFrontiers in microbiology · 2025Pooled it
- Transmission routes of antibiotic resistant bacteria: a systematic review.BMC infectious diseases · 2022Pooled it
- Article
- Prevalence of Selected Immune Evasion Genes and Clonal Diversity in Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2024Article
- Flesh Without Blood: The Public Health Benefits of Lab-Grown Meat.Journal of bioethical inquiry · 2024Article
- Emergence and Genomic Characterization of aMedicina (Kaunas, Lithuania) · 2024Article
- Industrial Hog Operation Workers' Perspectives on Occupational Exposure to Zoonotic Pathogens: A Qualitative Pilot Study in North Carolina, USA.New solutions : a journal of environmental and occupational health policy : NS · 2024Article
- Genome-based surveillance reveals cross-transmission of MRSA ST59 between humans and retail livestock products in Hanzhong, China.Frontiers in microbiology · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Reservoirs of antimicrobial resistance in the context of One Health.Current opinion in microbiology · 2023Review
- Evidence-based identification and characterization of methicillin-resistantIranian journal of veterinary research · 2023Article
- Exposure to industrial hog and poultry operations and urinary tract infections in North Carolina, USA.The Science of the total environment · 2022Article
- Whole-Genome Analysis ofFoods (Basel, Switzerland) · 2022Article
- Application of Markov models to predict changes in nasal carriage ofJournal of occupational and environmental hygiene · 2022Article
- Assessing Residential Exposure to Microbes from Industrial Hog Operations in Rural North Carolina: Methods and Lessons Learned.Progress in community health partnerships : research, education, and action · 2022Article
- Disinfectant and Antimicrobial Susceptibility Studies ofMicroorganisms · 2021Article
- Environmental Injustice and Industrial Chicken Farming in Maryland.International journal of environmental research and public health · 2021Article
- Ecology and Genetic Lineages of NasalPathogens (Basel, Switzerland) · 2021Review
- Getting ahead of antibiotic-resistant Staphylococcus aureus in U.S. hogs.Environmental research · 2021Article
- Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States.Emerging infectious diseases · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesAdministration of antibiotics to food animals may select for drug-resistant pathogens of clinical significance, such as methicillin-resistant Staphylococcus aureus (MRSA). In the United States, studies have examined prevalence of MRSA carriage among individuals exposed to livestock, but prevalence of multidrug-resistant S. aureus (MDRSA) carriage and the association with livestock raised with versus without antibiotic selective pressure remains unclear. We aimed to examine prevalence, antibiotic susceptibility, and molecular characteristics of S. aureus among industrial livestock operation (ILO) and antibiotic-free livestock operation (AFLO) workers and household members in North Carolina.
methodsParticipants in this cross-sectional study were interviewed and provided a nasal swab for S. aureus analysis. Resulting S. aureus isolates were assessed for antibiotic susceptibility, multi-locus sequence type, and absence of the scn gene (a marker of livestock association).
resultsAmong 99 ILO and 105 AFLO participants, S. aureus nasal carriage prevalence was 41% and 40%, respectively. Among ILO and AFLO S. aureus carriers, MRSA was detected in 7% (3/41) and 7% (3/42), respectively. Thirty seven percent of 41 ILO versus 19% of 42 AFLO S. aureus-positive participants carried MDRSA. S. aureus clonal complex (CC) 398 was observed only among workers and predominated among ILO (13/34) compared with AFLO (1/35) S. aureus-positive workers. Only ILO workers carried scn-negative MRSA CC398 (2/34) and scn-negative MDRSA CC398 (6/34), and all of these isolates were tetracycline resistant.
conclusionsDespite similar S. aureus and MRSA prevalence among ILO and AFLO-exposed individuals, livestock-associated MRSA and MDRSA (tetracycline-resistant, CC398, scn-negative) were only present among ILO-exposed individuals. These findings support growing concern about antibiotics use and confinement in livestock production, raising questions about the potential for occupational exposure to an opportunistic and drug-resistant pathogen, which in other settings including hospitals and the community is of broad public health importance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.