ArticlePloS one2013
UVB irradiation regulates ERK1/2- and p53-dependent thrombomodulin expression in human keratinocytes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts.International journal of molecular sciences · 2022Article
- The Role of microRNAs in Organismal and Skin Aging.International journal of molecular sciences · 2020Review
- Effects of Saccharides from Arctium lappa L. Root on FeClOxidative medicine and cellular longevity · 2020Article
- Thrombomodulin Regulation of Mitogen-Activated Protein Kinases.International journal of molecular sciences · 2019Review
- The application of transcriptional benchmark dose modeling for deriving thresholds of effects associated with solar-simulated ultraviolet radiation exposure.Environmental and molecular mutagenesis · 2018Article
- The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice.Blood advances · 2018Article
- Grifolic acid induces GH3 adenoma cell death by inhibiting ATP production through a GPR120-independent mechanism.BMC pharmacology & toxicology · 2018Article
- Extract fromEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis.Carcinogenesis · 2015Review
- Inhibitory effects of adlay extract on melanin production and cellular oxygen stress in B16F10 melanoma cells.International journal of molecular sciences · 2014Article
- Immunological visibility: posttranscriptional regulation of human NKG2D ligands by the EGF receptor pathway.Science translational medicine · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombomodulin (TM) is highly expressed in endothelial cells and acts as a natural anticoagulation factor to maintain circulation homeostasis. TM is an interesting molecule with many physiological functions, including anti-inflammation, anti-thrombosis, and carcinogenesis inhibition. TM can also be detected on the spinous layer of epidermal keratinocytes. However, the role of epidermal TM is still under investigation. In this study, we investigated keratinocyte TM expression and regulation in response to sub-cytotoxic ultraviolet B (UVB) irradiation. Oxidative stress was assessed with DCF and the results revealed that UVB irradiation significantly and dose-dependently augmented reactive oxygen species (ROS) production in HaCaT cells. In addition, low-dose UVB irradiation decreased TM mRNA and protein levels. Blocking ROS production and ERK activation prevented UVB-induced TM down-regulation. The nuclear p53 accumulation and TM promoter binding was observed within 3 h after UVB exposure. Small interfering RNA-mediated p53 knockdown disrupted the UVB-mediated TM protein down-regulation. Our study demonstrates that UVB irradiation results in ROS accumulation and ERK activation, which causes the nuclear p53 accumulation and TM promoter binding to inhibit TM expression. This study provides novel evidence demonstrating that p53 serves as a key regulator of keratinocyte TM expression.
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