Evidence map›Paper›PMID 23843984›Full record

SynthesisPloS one2013

The use of biatain Ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials.

David Leaper, Christian Münter, Sylvie Meaume, Alessandro Scalise, Nacho Blanes Mompó, Birte Petersen Jakobsen, Finn Gottrup

Abstract readMeta-Analysis
In one paragraph

Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David LeaperWound Healing Research Unit, Cardiff University, Cardiff, United Kingdom.
Christian Münter
Sylvie Meaume
Alessandro Scalise
Nacho Blanes Mompó
Birte Petersen Jakobsen
Finn Gottrup

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVenous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs).

aimTo evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing. PATIENTS AND

methods685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis.

resultsBiatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002).

conclusionThe meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.

Indexed as

AgedAged, 80 and overAnti-Infective Agents, LocalBandagesFemaleHumansMaleMiddle AgedPolyurethanesRandomized Controlled Trials as TopicSilver CompoundsTreatment OutcomeVaricose UlcerWound HealingAnti-Infective Agents, Localpolyurethane foamPolyurethanesSilver Compounds

Identifiers

PMID23843984
PMCPMC3699549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.