ArticleObstetrics and gynecology international2013
Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis.
Article in Obstetrics and gynecology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03136978 (Evaluation of Evaluate M1 and M2 Macrophages in Endometriotic Tissue of Women Affected by Endometriosis at Different Stages.), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Evaluate M1 and M2 Macrophages in Endometriotic Tissue of Women Affected by Endometriosis at Different Stages.
Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Prognostic significance of AP-2α/γ targets as cancer therapeutics.Scientific reports · 2022Article
- Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study.Journal of clinical medicine · 2020Article
- Management of ureteral endometriosis and review of the literature.Turkish journal of urology · 2019Article
- Circulating Endometrial Cells: A New Source of Information on Endometriosis Dynamics.Journal of clinical medicine · 2019Article
- G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.Stem cells (Dayton, Ohio) · 2018Article
- The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner.Oxidative medicine and cellular longevity · 2018Review
- Endometriosis origin from primordial germ cells.Organogenesis · 2017Review
- Full-Thickness Excision versus Shaving by Laparoscopy for Intestinal Deep Infiltrating Endometriosis: Rationale and Potential Treatment Options.BioMed research international · 2016Review
- The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis.Seminars in reproductive medicine · 2015Review
- The pleiotropic effects of vitamin D in gynaecological and obstetric diseases: an overview on a hot topic.BioMed research international · 2015Review
- Somatic stem cells and their dysfunction in endometriosis.Frontiers in surgery · 2014Review
- Oxidative Stress during Ovarian Torsion in Pediatric and Adolescent Patients: Changing The Perspective of The Disease.International journal of fertility & sterilityReview
- Evaluation of Risk Factors Associated with Endometriosis in Infertile Women.International journal of fertility & sterilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the genetic regulation of Müllerian structures development, a key role is played by Hoxa and Wnt clusters, because they lead the transcription of different genes according to the different phases of the organogenesis, addressing correctly cell-to-cell interactions, allowing, finally, the physiologic morphogenesis. Accumulating evidence is suggesting that dysregulation of Wnt and/or Hox genes may affect cell migration during organogenesis and differentiation of Müllerian structures of the female reproductive tract, with possible dislocation and dissemination of primordial endometrial stem cells in ectopic regions, which have high plasticity to differentiation. We hypothesize that during postpubertal age, under the influence of different stimuli, these misplaced and quiescent ectopic endometrial cells could acquire new phenotype, biological functions, and immunogenicity. So, these kinds of cells may differentiate, specializing in epithelium, glands, and stroma to form a functional ectopic endometrial tissue. This may provoke a breakdown in the peritoneal cavity homeostasis, with the consequent processes of immune alteration, documented by peripheral mononuclear cells recruitment and secretion of inflammatory cytokines in early phases and of angiogenic and fibrogenic cytokines in the late stages of the disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.