ArticlePLoS computational biology2013
Flux balance analysis of cyanobacterial metabolism: the metabolic network of Synechocystis sp. PCC 6803.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 252 citations in OpenAlex.
- Challenges and Vision for Standardization of Biopolymer Data Sets for Machine Learning.Biomacromolecules · 2026Review
- Metabolic engineering of Synechocystis sp. PCC 6803 for olivetolic acid production.Microbial cell factories · 2026Article
- From pond to platform: howJournal of bacteriology · 2026Review
- Living Photoanodes for Solar-Driven Water Oxidation.Chemical reviews · 2026Review
- PositionalThe New phytologist · 2025Article
- Self-sustained rhythmic behavior ofPNAS nexus · 2025Article
- Improving productivity of citramalate from COBiotechnology for biofuels and bioproducts · 2024Article
- A framework for understanding collective microbiome metabolism.Nature microbiology · 2024Review
- Insufficient Acetyl-CoA Pool Restricts the Phototrophic Production of Organic Acids in Model Cyanobacteria.International journal of molecular sciences · 2024Review
- Quantitative principles of microbial metabolism shared across scales.Nature microbiology · 2024Review
- A quantitative description of light-limited cyanobacterial growth using flux balance analysis.PLoS computational biology · 2024Article
- Disrupted HPlant molecular biology · 2024Article
- Article
- Optimal energy and redox metabolism in the cyanobacterium Synechocystis sp. PCC 6803.NPJ systems biology and applications · 2023Article
- FreeFlux: A Python Package for Time-Efficient Isotopically Nonstationary Metabolic Flux Analysis.ACS synthetic biology · 2023Article
- A Non-functional γ-Aminobutyric Acid Shunt Pathway in CyanobacteriumInternational journal of molecular sciences · 2023Article
- Photoautotrophic Growth Rate Enhancement ofBiology · 2022Article
- Trajectories for the evolution of bacterial COProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The NAC factor LpNAL delays leaf senescence by repressing two chlorophyll catabolic genes in perennial ryegrass.Plant physiology · 2022Article
- Patterning of the Autotrophic, Mixotrophic, and Heterotrophic Proteomes of Oxygen-Evolving CyanobacteriumFrontiers in microbiology · 2022Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacteria are versatile unicellular phototrophic microorganisms that are highly abundant in many environments. Owing to their capability to utilize solar energy and atmospheric carbon dioxide for growth, cyanobacteria are increasingly recognized as a prolific resource for the synthesis of valuable chemicals and various biofuels. To fully harness the metabolic capabilities of cyanobacteria necessitates an in-depth understanding of the metabolic interconversions taking place during phototrophic growth, as provided by genome-scale reconstructions of microbial organisms. Here we present an extended reconstruction and analysis of the metabolic network of the unicellular cyanobacterium Synechocystis sp. PCC 6803. Building upon several recent reconstructions of cyanobacterial metabolism, unclear reaction steps are experimentally validated and the functional consequences of unknown or dissenting pathway topologies are discussed. The updated model integrates novel results with respect to the cyanobacterial TCA cycle, an alleged glyoxylate shunt, and the role of photorespiration in cellular growth. Going beyond conventional flux-balance analysis, we extend the computational analysis to diurnal light/dark cycles of cyanobacterial metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.