ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Response selectivity is correlated to dendritic structure in parvalbumin-expressing inhibitory neurons in visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Condition-Dependent Noise Correlations without Condition-Dependent Spike Counts.bioRxiv : the preprint server for biology · 2026Article
- Feature selective inhibitory mechanisms enable expectation suppression in cortical microcircuits.Scientific reports · 2025Article
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- Emergence of co-tuning in inhibitory neurons as a network phenomenon mediated by randomness, correlations, and homeostatic plasticity.Science advances · 2024Article
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- Emergence of probabilistic representation in the neural network of primary visual cortex.iScience · 2022Article
- Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortex.eLife · 2021Article
- Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks.Science advances · 2021Article
- Commentary on: Peng, Y et al., Structured recurrent inhibition in the presubiculum could improve information processing.Pflugers Archiv : European journal of physiology · 2021Article
- GABAergic microcircuitry of fear memory encoding.Neurobiology of learning and memory · 2021Review
- Inhibitory stabilization and cortical computation.Nature reviews. Neuroscience · 2021Review
- Theory of neuronal perturbome in cortical networks.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Structural Correlates of CA2 and CA3 Pyramidal Cell Activity in Freely-Moving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Patterned perturbation of inhibition can reveal the dynamical structure of neural processing.eLife · 2020Article
- Auditory Long-Range Parvalbumin Cortico-Striatal Neurons.Frontiers in neural circuits · 2020Article
- Sensory- and Motor-Related Responses of Layer 1 Neurons in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Inhibitory microcircuits for top-down plasticity of sensory representations.Nature communications · 2019Article
- α4βδ GABANeuroscience · 2019Article
- Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.Nature neuroscience · 2018Article
- Visual Processing by Calretinin Expressing Inhibitory Neurons in Mouse Primary Visual Cortex.Scientific reports · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inhibitory neurons have been shown to perform a variety of functions within brain circuits, including shaping response functions in target cells. Still, how the properties of specific inhibitory neuron classes relate to their local circuits remains unclear. To better understand the distribution and origins of orientation selectivity in inhibitory neurons expressing the calcium binding protein parvalbumin (PV) in the mouse primary visual cortex, we labeled PV(+) neurons with red fluorescent protein (RFP) and targeted them for cell-attached electrophysiological recordings. PV(+) neurons could be broadly tuned or sharply tuned for orientation but tended to be more broadly tuned than unlabeled neurons on average. The dendritic morphology of PV(+) cells, revealed by intracellular labeling, was strongly correlated with tuning: highly tuned PV(+) neurons had shorter dendrites that branched nearer to the soma and had smaller dendritic fields overall, whereas broadly tuned PV(+) neurons had longer dendrites that branched farther from the soma, producing larger dendritic fields. High-speed two-photon calcium imaging of visual responses showed that the orientation preferences of highly tuned PV(+) neurons resembled the preferred orientations of neighboring cells. These results suggest that the diversity of the local neighborhood and the nature of dendritic sampling may both contribute to the response selectivity of PV(+) neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.