ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Proximodistal segregation of nonspatial information in CA3: preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 112 citations in OpenAlex.
- Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding.Nature communications · 2014Trial
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice.eLife · 2025Article
- A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.Current biology : CB · 2025Article
- Object-translocation induces event coding in the rat hippocampus.Communications biology · 2025Article
- Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation.Scientific reports · 2025Article
- Object location memories recruit distal CA1 and catecholaminergic inputs to proximodistal CA1.PloS one · 2025Article
- Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning.Brain structure & function · 2024Article
- Sharpening the blades of the dentate gyrus: how adult-born neurons differentially modulate diverse aspects of hippocampal learning and memory.The EMBO journal · 2023Review
- Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding.Nature communications · 2023Article
- Simultaneous 3D cellular positioning and apical dendritic morphology of transgenic fluorescent mouse CA3 hippocampal pyramidal neurons.Journal of neuroscience methods · 2023Article
- Parallel Pathways Provide Hippocampal Spatial Information to Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- Article
- Loss of functional heterogeneity along the CA3 transverse axis in aging.Current biology : CB · 2022Article
- Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1.Scientific reports · 2022Article
- Behavioral and Cellular Tagging in Young and in Early Cognitive Aging.Frontiers in aging neuroscience · 2022Article
- Article
- Distal CA1 Maintains a More Coherent Spatial Representation than Proximal CA1 When Local and Global Cues Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Lesion of the hippocampus selectively enhances LEC's activity during recognition memory based on familiarity.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prevailing view in memory research is that CA3 principally supports spatial processes. However, few studies have investigated the contribution of CA3 to nonspatial memory function. Interestingly, the proximal part of CA3 (close to the dentate gyrus) predominantly projects to distal CA1 (away from the dentate gyrus), which preferentially processes nonspatial information. Moreover, the cytoarchitecture and connectivity patterns in the proximal and distal parts of CA3 strongly differ, suggesting a functional segregation in this area. Here, we tested whether CA3 is recruited during nonspatial recognition memory, and whether nonspatial information is differentially represented along the proximodistal axis of CA3. Furthermore, we investigated whether the pattern of activation within CA3 would mirror that of CA1. We used a high-resolution imaging technique specifically designed to analyze brain activity in distant areas that is based on the detection of the expression of the immediate-early gene Arc, used as a marker of neuronal activation. We showed that proximal CA3 is strongly recruited during a nonspatial delayed nonmatching-to-sample recognition memory task in rats, while distal CA3 is not. In addition, distal CA1 was more activated than proximal CA1 in the same task. These findings suggest a functional segregation of CA3 that mirrors that of CA1, and potentially indicate the existence of a proximal CA3-distal CA1 hippocampal subnetwork that would preferentially process nonspatial information during recognition memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.