ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Reevaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 20 citations in OpenAlex.
- Purkinje Cell Spatial Correlation Dynamics Are Key to Cerebellar Cortical Contributions to Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nature communications · 2024Article
- What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?Cerebellum (London, England) · 2023Review
- Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching.The Journal of physiology · 2022Article
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.Neurobiology of disease · 2018Article
- Electrical Synapses Enhance and Accelerate Interneuron Recruitment in Response to Coincident and Sequential Excitation.Frontiers in cellular neuroscience · 2018Article
- Concerted Interneuron Activity in the Cerebellar Molecular Layer During Rhythmic Oromotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex.eLife · 2016Article
- Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits.Nature reviews. Neuroscience · 2015Review
- An excitatory GABA loop operating in vivo.Frontiers in cellular neuroscience · 2015Article
- Modeling possible effects of atypical cerebellar processing on eyeblink conditioning in autism.Cognitive, affective & behavioral neuroscience · 2014Article
- Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype.Frontiers in neural circuits · 2013Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The role of parallel fibers (PFs) in cerebellar physiology remains controversial. Early studies inspired the "beam" hypothesis whereby granule cell (GC) activation results in PF-driven, postsynaptic excitation of beams of Purkinje cells (PCs). However, the "radial" hypothesis postulates that the ascending limb of the GC axon provides the dominant input to PCs and generates patch-like responses. Using optical imaging and single-cell recordings in the mouse cerebellar cortex in vivo, this study reexamines the beam versus radial controversy. Electrical stimulation of mossy fibers (MFs) as well as microinjection of NMDA in the granular layer generates beam-like responses with a centrally located patch-like response. Remarkably, ipsilateral forepaw stimulation evokes a beam-like response in Crus I. Discrete molecular layer lesions demonstrate that PFs contribute to the peripherally generated responses in Crus I. In contrast, vibrissal stimulation induces patch-like activation of Crus II and GABAA antagonists fail to convert this patch-like activity into a beam-like response, implying that molecular layer inhibition does not prevent beam-like responses. However, blocking excitatory amino acid transporters (EAATs) generates beam-like responses in Crus II. These beam-like responses are suppressed by focal inhibition of MF-GC synaptic transmission. Using EAAT4 reporter transgenic mice, we show that peripherally evoked patch-like responses in Crus II are aligned between parasagittal bands of EAAT4. This is the first study to demonstrate beam-like responses in the cerebellar cortex to peripheral, MF, and GC stimulation in vivo. Furthermore, the spatial pattern of the responses depends on extracellular glutamate and its local regulation by EAATs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.