ArticleJournal of neurophysiology2013
Central dysmyelination reduces the temporal fidelity of synaptic transmission and the reliability of postsynaptic firing during high-frequency stimulation.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Scn2a-linked myelination deficits and synaptic plasticity alterations drive auditory processing disorders in an ASD mouse model.Nature communications · 2025Article
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.bioRxiv : the preprint server for biology · 2025Article
- Ambient sound stimulation tunes axonal conduction velocity by regulating radial growth of myelin on an individual, axon-by-axon basis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Loss of β4-spectrin impairs NaScientific reports · 2022Article
- Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia.Frontiers in neurology · 2022Article
- Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.Frontiers in neuroscience · 2022Article
- Axon-glia interactions in the ascending auditory system.Developmental neurobiology · 2021Review
- Neuron-Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells.Life (Basel, Switzerland) · 2021Review
- Neuronal input triggers CaGlia · 2019Article
- Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan.Frontiers in cellular neuroscience · 2019Article
- Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus.Scientific reports · 2018Article
- Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation.Nature communications · 2017Article
- Sound-Evoked Activity Influences Myelination of Brainstem Axons in the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Inflammatory demyelination alters subcortical visual circuits.Journal of neuroinflammation · 2017Article
- Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development.Journal of neurophysiology · 2017Article
- Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.Frontiers in cellular neuroscience · 2017Article
- Functional and structural properties of ion channels at the nerve terminal depends on compact myelin.The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Auditory brain stem circuits rely on fast, precise, and reliable neurotransmission to process auditory information. To determine the fundamental role of myelination in auditory brain stem function, we examined the evoked auditory brain stem response (ABR) from the Long Evans shaker (LES) rat, which lacks myelin due to a genetic deletion of myelin basic protein. In control rats, the ABR evoked by a click consisted of five well-defined waves (denoted waves I-V). In LES rats, waves I, IV, and V were present, but waves II and III were undetectable, indicating disrupted function in the earliest stages of central nervous system auditory processing. In addition, the developmental shortening of the interval between waves I and IV that normally occurs in control rats was arrested and resulted in a significant increase in the central conduction time in LES rats. In brain stem slices, action potential transmission between the calyx of Held terminals and the medial nucleus of the trapezoid body (MNTB) neurons was delayed and less reliable in LES rats, although the resting potential, threshold, input resistance, and length of the axon initial segment of the postsynaptic MNTB neurons were normal. The amplitude of glutamatergic excitatory postsynaptic currents (EPSCs) and the degree of synaptic depression during high-frequency stimulation were not different between LES rats and controls, but LES rats exhibited a marked slow component to the EPSC decay and a much higher rate of presynaptic failures. Together, these results indicate that loss of myelin disrupts brain stem auditory processing, increasing central conduction time and reducing the reliability of neurotransmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.